Amphiphilic PEO-b-PBLG Diblock and PBLG-b-PEO-b-PBLG Triblock Copolymer Based Nanoparticles: Doxorubicin Loading and In Vitro Evaluation
| dc.rights.license | open | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| hal.structure.identifier | Institute of Nuclear Medicine and Allied Sciences | |
| hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
| dc.contributor.author | KAKKAR, Dipti | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
| dc.contributor.author | MAZZAFERRO, Silvia | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
| dc.contributor.author | THEVENOT, Julie | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
| dc.contributor.author | SCHATZ, Christophe | |
| hal.structure.identifier | Institute of Nuclear Medicine and Allied Sciences | |
| dc.contributor.author | BHATT, Anant | |
| hal.structure.identifier | Institute of Nuclear Medicine and Allied Sciences | |
| dc.contributor.author | DWARAKANATH, Bilikere S. | |
| hal.structure.identifier | Indian Inst Technol, Ctr Biomed Engn | |
| dc.contributor.author | SINGH, Harpal | |
| hal.structure.identifier | Institute of Nuclear Medicine and Allied Sciences | |
| dc.contributor.author | MISHRA, Anil K. | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
| dc.contributor.author | LECOMMANDOUX, Sebastien | |
| dc.date.accessioned | 2020 | |
| dc.date.available | 2020 | |
| dc.date.issued | 2015 | |
| dc.identifier.issn | 1616-5187 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/20278 | |
| dc.description.abstractEn | Huisgen's 1,3-dipolar cycloaddition (Click Chemestry) has been used to prepare amphiphilic PEO-b-PBLG diblock and PBLG-b-PEO-b-PBLG triblock copolymers as potential carriers of anticancer drugs. Spherical and flower shaped micelles (D approximate to 100 nm) were obtained from diblock and triblock copolymers respectively. DOX was effectively encapsulated up to 18 wt.% and 50-60% of it was steadily released from the micelles over a period of 7 d. Flow cytometry and fluorescence microscopy confirmed the effective intracellular uptake as well as the sustained release of DOX from micelles. These results suggest that the diblock as well as triblock copolymers are promising carriers for intra-cellular drug delivery. | |
| dc.language.iso | en | |
| dc.publisher | Wiley-VCH Verlag | |
| dc.subject.en | click chemistry | |
| dc.subject.en | ANTITUMOR-ACTIVITY | |
| dc.subject.en | INTRACELLULAR DELIVERY | |
| dc.subject.en | BIOMEDICAL APPLICATIONS | |
| dc.subject.en | THERAPEUTIC APPLICATIONS | |
| dc.subject.en | block-copolymers | |
| dc.subject.en | POLY(ETHYLENE OXIDE) | |
| dc.subject.en | ROD-COIL | |
| dc.subject.en | DRUG-DELIVERY | |
| dc.subject.en | POLYMERIC MICELLES | |
| dc.subject.en | POLY(GAMMA-BENZYL L-GLUTAMATE) | |
| dc.subject.en | PBLG | |
| dc.subject.en | PEO | |
| dc.subject.en | BLOCK-COPOLYMER | |
| dc.subject.en | nanoparticles | |
| dc.title.en | Amphiphilic PEO-b-PBLG Diblock and PBLG-b-PEO-b-PBLG Triblock Copolymer Based Nanoparticles: Doxorubicin Loading and In Vitro Evaluation | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1002/mabi.201400451 | |
| dc.subject.hal | Chimie/Polymères | |
| bordeaux.journal | Macromolecular Bioscience | |
| bordeaux.page | 124-137 | |
| bordeaux.volume | 15 | |
| bordeaux.hal.laboratories | Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629 | * |
| bordeaux.issue | 1 | |
| bordeaux.institution | Bordeaux INP | |
| bordeaux.institution | Université de Bordeaux | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-01357683 | |
| hal.version | 1 | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-01357683v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Macromolecular%20Bioscience&rft.date=2015&rft.volume=15&rft.issue=1&rft.spage=124-137&rft.epage=124-137&rft.eissn=1616-5187&rft.issn=1616-5187&rft.au=KAKKAR,%20Dipti&MAZZAFERRO,%20Silvia&THEVENOT,%20Julie&SCHATZ,%20Christophe&BHATT,%20Anant&rft.genre=article |
Fichier(s) constituant ce document
| Fichiers | Taille | Format | Vue |
|---|---|---|---|
|
Il n'y a pas de fichiers associés à ce document. |
|||