Amphiphilic PEO-b-PBLG Diblock and PBLG-b-PEO-b-PBLG Triblock Copolymer Based Nanoparticles: Doxorubicin Loading and In Vitro Evaluation
KAKKAR, Dipti
Laboratoire de Chimie des Polymères Organiques [LCPO]
Institute of Nuclear Medicine and Allied Sciences
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Laboratoire de Chimie des Polymères Organiques [LCPO]
Institute of Nuclear Medicine and Allied Sciences
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
MAZZAFERRO, Silvia
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
THEVENOT, Julie
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
See more >
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
KAKKAR, Dipti
Laboratoire de Chimie des Polymères Organiques [LCPO]
Institute of Nuclear Medicine and Allied Sciences
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Laboratoire de Chimie des Polymères Organiques [LCPO]
Institute of Nuclear Medicine and Allied Sciences
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
MAZZAFERRO, Silvia
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
THEVENOT, Julie
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
SCHATZ, Christophe
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
LECOMMANDOUX, Sebastien
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
< Reduce
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Language
en
Article de revue
This item was published in
Macromolecular Bioscience. 2015, vol. 15, n° 1, p. 124-137
Wiley-VCH Verlag
English Abstract
Huisgen's 1,3-dipolar cycloaddition (Click Chemestry) has been used to prepare amphiphilic PEO-b-PBLG diblock and PBLG-b-PEO-b-PBLG triblock copolymers as potential carriers of anticancer drugs. Spherical and flower shaped ...Read more >
Huisgen's 1,3-dipolar cycloaddition (Click Chemestry) has been used to prepare amphiphilic PEO-b-PBLG diblock and PBLG-b-PEO-b-PBLG triblock copolymers as potential carriers of anticancer drugs. Spherical and flower shaped micelles (D approximate to 100 nm) were obtained from diblock and triblock copolymers respectively. DOX was effectively encapsulated up to 18 wt.% and 50-60% of it was steadily released from the micelles over a period of 7 d. Flow cytometry and fluorescence microscopy confirmed the effective intracellular uptake as well as the sustained release of DOX from micelles. These results suggest that the diblock as well as triblock copolymers are promising carriers for intra-cellular drug delivery.Read less <
English Keywords
click chemistry
ANTITUMOR-ACTIVITY
INTRACELLULAR DELIVERY
BIOMEDICAL APPLICATIONS
THERAPEUTIC APPLICATIONS
block-copolymers
POLY(ETHYLENE OXIDE)
ROD-COIL
DRUG-DELIVERY
POLYMERIC MICELLES
POLY(GAMMA-BENZYL L-GLUTAMATE)
PBLG
PEO
BLOCK-COPOLYMER
nanoparticles
Origin
Hal imported