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A stable microtubule array drives fission yeast polarity reestablishment upon quiescence exit

hal.structure.identifierInstitut de biochimie et génétique cellulaires [IBGC]
dc.contributor.authorLAPORTE, Damien
hal.structure.identifierInstitut de biochimie et génétique cellulaires [IBGC]
dc.contributor.authorCOURTOUT, Fabien
hal.structure.identifierInstitut de biochimie et génétique cellulaires [IBGC]
dc.contributor.authorPINSON, Benoît
hal.structure.identifierInstitut de biochimie et génétique cellulaires [IBGC]
dc.contributor.authorDOMPIERRE, Jim
hal.structure.identifierInstitut de biochimie et génétique cellulaires [IBGC]
dc.contributor.authorSALIN, Bénédicte
hal.structure.identifierBiologie du fruit et pathologie [BFP]
hal.structure.identifierInstitut National de la Recherche Agronomique [INRA]
hal.structure.identifierUniversité de Bordeaux [UB]
dc.contributor.authorBROCARD, Lysiane
hal.structure.identifierInstitut de biochimie et génétique cellulaires [IBGC]
dc.contributor.authorSAGOT, Isabelle
dc.date.accessioned2024-10-23T02:05:43Z
dc.date.available2024-10-23T02:05:43Z
dc.date.issued2015-07-06
dc.identifier.issn0021-9525
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/202681
dc.description.abstractEnCells perpetually face the decision to proliferate or to stay quiescent. Here we show that upon quiescence establishment, Schizosaccharomyces pombe cells drastically rearrange both their actin and microtubule (MT) cytoskeletons and lose their polarity. Indeed, while polarity markers are lost from cell extremities, actin patches and cables are reorganized into actin bodies, which are stable actin filament–containing structures. Astonishingly, MTs are also stabilized and rearranged into a novel antiparallel bundle associated with the spindle pole body, named Q-MT bundle. We have identified proteins involved in this process and propose a molecular model for Q-MT bundle formation. Finally and importantly, we reveal that Q-MT bundle elongation is involved in polarity reestablishment upon quiescence exit and thereby the efficient return to the proliferative state. Our work demonstrates that quiescent S. pombe cells assemble specific cytoskeleton structures that improve the swiftness of the transition back to proliferation.
dc.language.isoen
dc.publisherRockefeller University Press
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/
dc.subject.enbenzimidazol-2-yl-carbamate
dc.subject.enMPA
dc.subject.enmycophenolic acid
dc.subject.enMT
dc.subject.enmicrotubule
dc.subject.enMTOC
dc.subject.enMT organizing center
dc.subject.enSPB
dc.subject.enbenzimidazol-2-yl-carbamate MPA
dc.subject.enmycophenolic acid MT
dc.subject.enmicrotubule MTOC
dc.subject.enMT organizing center SPB
dc.subject.enspindle pole
dc.title.enA stable microtubule array drives fission yeast polarity reestablishment upon quiescence exit
dc.typeArticle de revue
dc.identifier.doi10.1083/jcb.201502025
dc.subject.halSciences du Vivant [q-bio]
bordeaux.journalJournal of Cell Biology
bordeaux.page99-113
bordeaux.volume210
bordeaux.hal.laboratoriesBiologie du Fruit & Pathologie (BFP) - UMR 1332*
bordeaux.issue1
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionINRAE
bordeaux.peerReviewedoui
hal.identifierhal-04746272
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-04746272v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Cell%20Biology&rft.date=2015-07-06&rft.volume=210&rft.issue=1&rft.spage=99-113&rft.epage=99-113&rft.eissn=0021-9525&rft.issn=0021-9525&rft.au=LAPORTE,%20Damien&COURTOUT,%20Fabien&PINSON,%20Beno%C3%AEt&DOMPIERRE,%20Jim&SALIN,%20B%C3%A9n%C3%A9dicte&rft.genre=article


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