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Varicella-zoster virus in actively spreading segmental vitiligo skin: Pathological, immunochemical, and ultrastructural findings (a first and preliminary study).

dc.rights.licenseopenen_US
dc.contributor.authorGAUTHIER, Yvon
dc.contributor.authorLEPREUX, Sebastien
hal.structure.identifierBoRdeaux Institute in onCology [Inserm U1312 - BRIC]
dc.contributor.authorCARIO-ANDRE, Muriel
dc.contributor.authorRAMBERT, Jérome
dc.contributor.authorDAKDAKI, Adrien
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorLAFON, Marie-Edith
dc.contributor.authorABOUQAL, Redouane
dc.contributor.authorBENZEKRI, Laila
dc.date.accessioned2024-09-30T09:55:06Z
dc.date.available2024-09-30T09:55:06Z
dc.date.issued2023-01-01
dc.identifier.issn1755-148Xen_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/202024
dc.description.abstractEnSegmental vitiligo (SV) is a unilateral subtype of vitiligo which is clinically characterized by a cutaneous depigmentation and histologically by a melanocyte loss from the epidermis and hair follicle reservoirs. To date, its pathogenesis remains a mystery. In many cases, this skin depigmentation shares several clinical features and dysfunctions with herpes zoster (HZ). So, for the first time, we examined whether any nucleus and cell fusion associated with a positive immunolabelling of varicella-zoster virus (VZV) and VZV mature virions could be found in SV skin samples as in herpes zoster (HZ). A total of 40 SV samples were used for histological and immunochemical studies. Control samples were obtained from three HZ, and 10 generalized vitiligo lesions. For ultrastructural study, three recent SV and one HZ as controls were recruited. Here, we report that nuclear fusion in epidermal cells were statistically associated with recent SV (p < .001), whereas syncytia formation was associated with long-lasting SV (p = .001). A positive detection of VZV antigen was statistically associated in the epidermis with recent SV and in the dermis with long-lasting SV (p = .001). Finally, the discovery of mature virions in 3/3 recent SV samples provides additional arguments for our viral hypothesis.
dc.language.isoENen_US
dc.subject.enHumans
dc.subject.enHerpesvirus 3
dc.subject.enHuman
dc.subject.enVitiligo
dc.subject.enSkin
dc.subject.enHerpes Zoster
dc.subject.enMelanocytes
dc.title.enVaricella-zoster virus in actively spreading segmental vitiligo skin: Pathological, immunochemical, and ultrastructural findings (a first and preliminary study).
dc.title.alternativePigment Cell Melanoma Resen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1111/pcmr.13064en_US
dc.subject.halSciences du Vivant [q-bio]/Microbiologie et Parasitologieen_US
dc.identifier.pubmed36112095en_US
bordeaux.journalPigment Cell & Melanoma researchen_US
bordeaux.page78-85en_US
bordeaux.volume36en_US
bordeaux.hal.laboratoriesMFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234en_US
bordeaux.issue1en_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04714374
hal.version1
hal.date.transferred2024-09-30T09:55:09Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Pigment%20Cell%20&%20Melanoma%20research&amp;rft.date=2023-01-01&amp;rft.volume=36&amp;rft.issue=1&amp;rft.spage=78-85&amp;rft.epage=78-85&amp;rft.eissn=1755-148X&amp;rft.issn=1755-148X&amp;rft.au=GAUTHIER,%20Yvon&amp;LEPREUX,%20Sebastien&amp;CARIO-ANDRE,%20Muriel&amp;RAMBERT,%20J%C3%A9rome&amp;DAKDAKI,%20Adrien&amp;rft.genre=article


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