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hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierLaboratoire de chimie de coordination [LCC]
dc.contributor.authorBONDUELLE, Colin
IDREF: 134527046
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierINSERM, U1026, Tissue Bioengn, Univ Bordeaux
dc.contributor.authorDE OLIVEIRA, Hugo
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorGAUCHE, Cony
hal.structure.identifierDublin City Univ, Sci Chem Sci
dc.contributor.authorHUANG, Jin
hal.structure.identifierDublin City Univ, Sci Chem Sci
hal.structure.identifierPol Chem & Biomat Lab, Dept Pharmaceut & Med Chem, Dublin
dc.contributor.authorHEISE, Andreas
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2016
dc.identifier.issn1359-7345
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/20198
dc.description.abstractEnSynthetic glycopolypeptides are versatile glycopolymers used to conceive bioinspired nanoassemblies. In this work, novel amphiphilic glycopolypeptides were designed to incorporate lactose or galactan in order to prepare polymeric nanoassemblies with sizes below 50 nm. The bioactivity of the two different outer surface sugar units was evaluated by defining glycan relative binding affinities to human galectins 1 and 3. A specific multivalent effect was found only for polymeric nanoparticles displaying galactan with a significant increase of the binding activity as compared to free glycan in solution. Such synthetic designs present great potential as therapeutic tools to address galectin related pathologies.
dc.language.isoen
dc.publisherRoyal Society of Chemistry
dc.title.enMultivalent effect of glycopolypeptide based nanoparticles for galectin binding
dc.typeArticle de revue
dc.identifier.doi10.1039/c6cc06437j
dc.subject.halChimie/Polymères
bordeaux.journalChemical Communications
bordeaux.page11251-11254
bordeaux.volume52
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue75
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-01372522
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01372522v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Chemical%20Communications&rft.date=2016&rft.volume=52&rft.issue=75&rft.spage=11251-11254&rft.epage=11251-11254&rft.eissn=1359-7345&rft.issn=1359-7345&rft.au=BONDUELLE,%20Colin&DE%20OLIVEIRA,%20Hugo&GAUCHE,%20Cony&HUANG,%20Jin&HEISE,%20Andreas&rft.genre=article


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