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A Photoactivable Natural Product with Broad Antiviral Activity against Enveloped Viruses, Including Highly Pathogenic Coronaviruses

dc.rights.licenseopenen_US
dc.contributor.authorMEUNIER, Thomas
dc.contributor.authorDESMARETS, Lowiese
dc.contributor.authorBORDAGE, Simon
dc.contributor.authorBAMBA, Moussa
dc.contributor.authorHERVOUET, Kevin
dc.contributor.authorROUILLE, Yves
dc.contributor.authorFRANÇOIS, Nathan
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorDECOSSAS, Marion
dc.contributor.authorSENCIO, Valentin
dc.contributor.authorTROTTEIN, Francois
dc.contributor.authorTRA BI, Fezan Honora
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorLAMBERT, Olivier
dc.contributor.authorDUBUISSON, Jean
dc.contributor.authorBELOUZARD, Sandrine
dc.contributor.authorSAHPAZ, Sevser
dc.contributor.authorSÉRON, Karin
dc.date.accessioned2024-09-26T08:17:21Z
dc.date.available2024-09-26T08:17:21Z
dc.date.issued2022-02-15
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/201837
dc.description.abstractEnThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak has highlighted the need for broad-spectrum antivirals against coronaviruses (CoVs). Here, pheophorbide a (Pba) was identified as a highly active antiviral molecule against human CoV-229E after bioguided fractionation of plant extracts. The antiviral activity of Pba was subsequently shown for SARS-CoV-2 and Middle East respiratory syndrome coronavirus (MERS-CoV), and its mechanism of action was further assessed, showing that Pba is an inhibitor of coronavirus entry by directly targeting the viral particle. Interestingly, the antiviral activity of Pba depends on light exposure, and Pba was shown to inhibit virus-cell fusion by stiffening the viral membrane, as demonstrated by cryoelectron microscopy. Moreover, Pba was shown to be broadly active against several other enveloped viruses and reduced SARS-CoV-2 and MERS-CoV replication in primary human bronchial epithelial cells. Pba is the first described natural antiviral against SARS-CoV-2 with direct photosensitive virucidal activity that holds potential for COVID-19 therapy or disinfection of SARS-CoV-2-contaminated surfaces.
dc.language.isoENen_US
dc.subject.enAntiviral agents
dc.subject.enCoronavirus
dc.subject.enNatural product
dc.subject.enVirus entry
dc.title.enA Photoactivable Natural Product with Broad Antiviral Activity against Enveloped Viruses, Including Highly Pathogenic Coronaviruses
dc.typeArticle de revueen_US
dc.identifier.doi10.1128/AAC.01581-21en_US
dc.subject.halChimie/Matériauxen_US
dc.identifier.pubmed34807755en_US
bordeaux.journalAntimicrobial Agents and Chemotherapyen_US
bordeaux.volume66en_US
bordeaux.hal.laboratoriesCBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248en_US
bordeaux.issue2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Antimicrobial%20Agents%20and%20Chemotherapy&rft.date=2022-02-15&rft.volume=66&rft.issue=2&rft.au=MEUNIER,%20Thomas&DESMARETS,%20Lowiese&BORDAGE,%20Simon&BAMBA,%20Moussa&HERVOUET,%20Kevin&rft.genre=article


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