Controlling Superselectivity of Multivalent Interactions with Cofactors and Competitors
| dc.rights.license | open | en_US |
| dc.contributor.author | CURK, Tine | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | DUBACHEVA, Galina V. | |
| dc.contributor.author | BRISSON, Alain R. | |
| dc.contributor.author | RICHTER, Ralf P. | |
| dc.date.accessioned | 2024-09-20T13:08:51Z | |
| dc.date.available | 2024-09-20T13:08:51Z | |
| dc.date.issued | 2022-09-28 | |
| dc.identifier.issn | 0002-7863 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/201713 | |
| dc.description.abstractEn | Moieties that compete with multivalent interactions or act as cofactors are common in living systems, but their effect on multivalent binding remains poorly understood. We derive a theoretical model that shows how the superselectivity of multivalent interactions is modulated by the presence of cofactors or competitors. We find that the role of these participating moieties can be fully captured by a simple rescaling of the affinity constant of the individual ligand–receptor bonds. Theoretical predictions are supported by experimental data of the membrane repair protein annexin A5 binding to anionic lipid membranes in the presence of Ca2+ cofactors and of the extracellular matrix polysaccharide hyaluronan (HA) binding to CD44 cell surface receptors in the presence of HA oligosaccharide competitors. The obtained findings should facilitate understanding of multivalent recognition in biological systems and open new routes for fine-tuning the selectivity of multivalent nanoprobes in medicinal chemistry. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
| dc.title.en | Controlling Superselectivity of Multivalent Interactions with Cofactors and Competitors | |
| dc.title.alternative | J. Am. Chem. Soc. | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1021/jacs.2c06942 | en_US |
| dc.subject.hal | Chimie/Matériaux | en_US |
| dc.identifier.pubmed | 36103600 | en_US |
| dc.description.sponsorshipEurope | Biomolecular Hydrogels – from Supramolecular Organization and Dynamics to Biological Function | en_US |
| dc.description.sponsorshipEurope | Combining supramolecular chemistry, physico-chemical characterization and theoretical modeling to understand multivalent interactions at the cell-hyaluronan matrix interface | en_US |
| bordeaux.journal | Journal of the American Chemical Society | en_US |
| bordeaux.page | 17346-17350 | en_US |
| bordeaux.volume | 144 | en_US |
| bordeaux.hal.laboratories | CBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248 | en_US |
| bordeaux.issue | 38 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | Bordeaux INP | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| dc.rights.cc | CC BY-NC-ND | en_US |
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