Associations of inner retinal layers with risk of incident dementia: An individual participant data analysis of four prospective cohort studies
| dc.rights.license | open | en_US |
| dc.contributor.author | VAN DER HEIDE, Frank C T | |
| dc.contributor.author | KHAWAJA, Anthony | |
| dc.contributor.author | BERENDSCHOT, Tos T J M | |
| dc.contributor.author | LITTLEJOHNS, Thomas J | |
| dc.contributor.author | KUŹMA, Elżbieta | |
| dc.contributor.author | LUBEN, Robert | |
| dc.contributor.author | PATEL, Praveen J | |
| dc.contributor.author | FOSTER, Paul J | |
| dc.contributor.author | BERTELSEN, Geir | |
| dc.contributor.author | VON HANNO, Therese | |
| dc.contributor.author | JOHNSEN, Bente | |
| dc.contributor.author | SCHIRMER, Henrik | |
| dc.contributor.author | REBOUÇAS, Sara C L | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | GRASSET, Leslie | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DELCOURT, Cecile | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | HELMER, Catherine | |
| dc.contributor.author | STEHOUWER, Coen D A | |
| dc.date.accessioned | 2024-09-19T13:01:02Z | |
| dc.date.available | 2024-09-19T13:01:02Z | |
| dc.date.issued | 2024-01-01 | |
| dc.identifier.issn | 1552-5279 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/201694 | |
| dc.description.abstractEn | Our main objective was to investigate whether retinal neurodegeneration, estimated from lower thickness of inner retinal layers, was associated with incident all-cause dementia and Alzheimer's disease (AD). We performed an individual participant data meta-analysis using unpublished data from four prospective cohort studies with a total of 69,955 participants (n = 1087 cases of incident all-cause dementia; n = 520 cases incident AD; follow-up time median [interquartile range] 11.3 [8.8-11.5] years). General baseline characteristics of the study population were mean (standard deviation) age, 58.1 (8.8) years; 47% women. After adjustment, lower baseline macular retinal nerve fiber layer thickness was significantly associated with a 10% and 11% higher incidence of all-cause dementia and AD, respectively. Lower baseline macular ganglion cell-inner plexiform layer thickness was not significantly associated with these outcomes. These findings suggest that retinal neurodegeneration precedes the onset of clinical dementia. Retinal imaging tools may be informative biomarkers for the study of the early pathophysiology of dementia. | |
| dc.description.sponsorship | Histoire naturelle du déclin cognitif et du besoin de soins chez le sujet âgé | en_US |
| dc.description.sponsorship | Dysfonctions vasculaires, cognitives et neurologiques du sujet âgé : l'influence de l'hyperhomocystéinémie sur la régulation épigénétique de gènes candidats | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
| dc.subject.en | Humans | |
| dc.subject.en | Female | |
| dc.subject.en | Middle Aged | |
| dc.subject.en | Male | |
| dc.subject.en | Prospective Studies | |
| dc.subject.en | Tomography | |
| dc.subject.en | Optical Coherence | |
| dc.subject.en | Retina | |
| dc.subject.en | Alzheimer Disease | |
| dc.subject.en | Data Analysis | |
| dc.title.en | Associations of inner retinal layers with risk of incident dementia: An individual participant data analysis of four prospective cohort studies | |
| dc.title.alternative | Alzheimers Dement | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1002/alz.13167 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 37551793 | en_US |
| bordeaux.journal | Alzheimer's & Dementia : the Journal of the Alzheimer's Association | en_US |
| bordeaux.page | 211-220 | en_US |
| bordeaux.volume | 20 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 1 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | LEHA_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Fondation pour la Recherche Médicale | en_US |
| bordeaux.identifier.funderID | Fondation Plan Alzheimer | en_US |
| bordeaux.identifier.funderID | Mutuelle Générale de l'Education Nationale | en_US |
| bordeaux.identifier.funderID | Agence Française de Sécurité Sanitaire des Produits de Santé | en_US |
| bordeaux.identifier.funderID | Caisse nationale de solidarité pour l'autonomie | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-04702653 | |
| hal.version | 1 | |
| hal.date.transferred | 2024-09-19T13:01:07Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Alzheimer's%20&%20Dementia%20:%20the%20Journal%20of%20the%20Alzheimer's%20Association&rft.date=2024-01-01&rft.volume=20&rft.issue=1&rft.spage=211-220&rft.epage=211-220&rft.eissn=1552-5279&rft.issn=1552-5279&rft.au=VAN%20DER%20HEIDE,%20Frank%20C%20T&KHAWAJA,%20Anthony&BERENDSCHOT,%20Tos%20T%20J%20M&LITTLEJOHNS,%20Thomas%20J&KU%C5%B9MA,%20El%C5%BCbieta&rft.genre=article |
