Show simple item record

Elevated levels of circulatory follicular T helper cells in chronic lymphocytic leukemia contribute to B cell expansion

dc.rights.licenseopenen_US
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorLE SAOS-PATRINOS, Corentin
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorLOIZON, Severine
dc.contributor.authorZOUINE, Atika
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorTURPIN, Delphine
dc.contributor.authorDILHUYDY, Marie-Sarah
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorBLANCO, Patrick
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorSISIRAK, Vanja
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorFORCADE, Edouard
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorDULUC, Dorothee
dc.date.accessioned2024-09-17T09:40:51Z
dc.date.available2024-09-17T09:40:51Z
dc.date.issued2023-03
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/201620
dc.description.abstractEnChronic lymphocytic leukemia (CLL) is characterized by an expansion of mature B cells in the bone marrow, peripheral lymphoid organs, and blood. CD4 T helper (Th) lymphocytes significantly contribute to the physiopathology of CLL, but the subset(s) of Th cell involved in CLL pathogenesis is (are) still under debate. In this study, we performed flow cytometry analysis of the circulatory T cells of untreated CLL patients and observed an increase in follicular helper T cells (Tfh), which is a subset of T cells specialized in B cell help. Elevated numbers of Tfh cells correlated with disease severity as measured by the Binet staging system. Tfh from CLL patients were activated and skewed toward a Th1 profile as evidenced by their PD-1+IL-21+IFNγ+ phenotype and their CXCR3+CCR6- chemokine receptor profile. Tfh efficiently enhanced B-CLL survival and proliferation through IL-21 but independently of IFNγ. Finally, we observed an inverse correlation between the Tfh1 and IgA and IgG serum levels in patients, suggesting a role for this Tfh subset in the immune dysfunction associated with CLL. Altogether, our data highlight an impairment in circulatory Tfh subsets in CLL patients and their critical role in CLL physiopathology. © The Author(s) 2023. Published by Oxford University Press on behalf of Society for Leukocyte Biology.
dc.language.isoENen_US
dc.subject.enTfh1
dc.subject.enIL-21
dc.subject.enIFNγ
dc.subject.enCLL
dc.subject.entumor
dc.title.enElevated levels of circulatory follicular T helper cells in chronic lymphocytic leukemia contribute to B cell expansion
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/jleuko/qiad006en_US
dc.subject.halSciences du Vivant [q-bio]/Immunologieen_US
dc.identifier.pubmed36807447en_US
bordeaux.journalJournal of Leukocyte Biologyen_US
bordeaux.page305-314en_US
bordeaux.volume113en_US
bordeaux.hal.laboratoriesImmunoConcEpT - UMR 5164en_US
bordeaux.issue3en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Leukocyte%20Biology&rft.date=2023-03&rft.volume=113&rft.issue=3&rft.spage=305-314&rft.epage=305-314&rft.au=LE%20SAOS-PATRINOS,%20Corentin&LOIZON,%20Severine&ZOUINE,%20Atika&TURPIN,%20Delphine&DILHUYDY,%20Marie-Sarah&rft.genre=article


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record