LE SAOS-PATRINOS, Corentin; LOIZON, Severine; ZOUINE, Atika; TURPIN, Delphine; DILHUYDY, Marie-Sarah; BLANCO, Patrick; SISIRAK, Vanja; FORCADE, Edouard; DULUC, Dorothee

doi:10.1093/jleuko/qiad006

Métadonnées

Licence d’utilisation du document

LE SAOS-PATRINOS, Corentin
Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

LOIZON, Severine
Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

ZOUINE, Atika

Langue

Article de revue

Ce document a été publié dans

Journal of Leukocyte Biology. 2023-03, vol. 113, n° 3, p. 305-314

Résumé en anglais

Chronic lymphocytic leukemia (CLL) is characterized by an expansion of mature B cells in the bone marrow, peripheral lymphoid organs, and blood. CD4 T helper (Th) lymphocytes significantly contribute to the physiopathology of CLL, but the subset(s) of Th cell involved in CLL pathogenesis is (are) still under debate. In this study, we performed flow cytometry analysis of the circulatory T cells of untreated CLL patients and observed an increase in follicular helper T cells (Tfh), which is a subset of T cells specialized in B cell help. Elevated numbers of Tfh cells correlated with disease severity as measured by the Binet staging system. Tfh from CLL patients were activated and skewed toward a Th1 profile as evidenced by their PD-1+IL-21+IFNγ+ phenotype and their CXCR3+CCR6- chemokine receptor profile. Tfh efficiently enhanced B-CLL survival and proliferation through IL-21 but independently of IFNγ. Finally, we observed an inverse correlation between the Tfh1 and IgA and IgG serum levels in patients, suggesting a role for this Tfh subset in the immune dysfunction associated with CLL. Altogether, our data highlight an impairment in circulatory Tfh subsets in CLL patients and their critical role in CLL physiopathology. © The Author(s) 2023. Published by Oxford University Press on behalf of Society for Leukocyte Biology.< Réduire

Mots clés en anglais

Tfh1

IL-21

IFNγ

CLL

tumor

Métadonnées

Partager cette publication !

Licence d’utilisation du document

Elevated levels of circulatory follicular T helper cells in chronic lymphocytic leukemia contribute to B cell expansion

Langue

Ce document a été publié dans

Résumé en anglais

Mots clés en anglais

URI

DOI

Unités de recherche