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Decreased telomere length in a subgroup of young individuals with bipolar disorders: replication in the FACE-BD cohort and association with the shelterin component POT1

dc.rights.licenseopenen_US
dc.contributor.authorSPANO, Luana
dc.contributor.authorMARIE-CLAIRE, Cynthia
dc.contributor.authorGODIN, Ophélia
dc.contributor.authorLEBRAS, Apolline
dc.contributor.authorCOURTIN, Cindie
dc.contributor.authorLAPLANCHE, Jean-Louis
dc.contributor.authorLEBOYER, Marion
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAOUIZERATE, Bruno
dc.contributor.authorLEFRERE, Antoine
dc.contributor.authorBELZEAUX, Raoul
dc.contributor.authorCOURTET, Philippe
dc.contributor.authorOLIÉ, Emilie
dc.contributor.authorDUBERTRET, Caroline
dc.contributor.authorSCHWAN, Raymund
dc.contributor.authorAUBIN, Valérie
dc.contributor.authorROUX, Paul
dc.contributor.authorPOLOSAN, Mircea
dc.contributor.authorSAMALIN, Ludovic
dc.contributor.authorHAFFEN, Emmanuel
dc.contributor.authorBELLIVIER, Frank
dc.contributor.authorETAIN, Bruno
dc.date.accessioned2024-09-04T09:23:52Z
dc.date.available2024-09-04T09:23:52Z
dc.date.issued2024-03-01
dc.identifier.issn2158-3188en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/201420
dc.description.abstractEnBipolar disorder (BD) has been associated with premature cellular aging with shortened telomere length (TL) as compared to the general population. We recently identified a subgroup of young individuals with prematurely shortened TL. The aims of the present study were to replicate this observation in a larger sample and analyze the expression levels of genes associated with age or TL in a subsample of these individuals. TL was measured on peripheral blood DNA using quantitative polymerase chain reaction in a sample of 542 individuals with BD and clustering analyses were performed. Gene expression level of 29 genes, associated with aging or with telomere maintenance, was analyzed in RNA samples from a subsample of 129 individuals. Clustering analyses identified a group of young individuals (mean age 29.64 years), with shorter TL. None of the tested clinical variables were significantly associated with this subgroup. Gene expression level analyses showed significant downregulation of MYC, POT1, and CD27 in the prematurely aged young individuals compared to the young individuals with longer TL. After adjustment only POT1 remained significantly differentially expressed between the two groups of young individuals. This study confirms the existence of a subgroup of young individuals with BD with shortened TL. The observed decrease of POT1 expression level suggests a newly described cellular mechanism in individuals with BD, that may contribute to telomere shortening.
dc.description.sponsorshipSorbonne Universités à Paris pour l'Enseignement et la Rechercheen_US
dc.description.sponsorshipFondaMental-Cohortes - ANR-10-COHO-0010en_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enAdult
dc.subject.enAged
dc.subject.enHumans
dc.subject.enAging
dc.subject.enAging
dc.subject.enPremature
dc.subject.enBipolar Disorder
dc.subject.enShelterin Complex
dc.subject.enTelomere
dc.subject.enTelomere Shortening
dc.subject.enTelomere-Binding Proteins
dc.title.enDecreased telomere length in a subgroup of young individuals with bipolar disorders: replication in the FACE-BD cohort and association with the shelterin component POT1
dc.title.alternativeTransl Psychiatryen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41398-024-02824-zen_US
dc.identifier.pubmed38429270en_US
bordeaux.journalTranslational Psychiatryen_US
bordeaux.page131en_US
bordeaux.volume14en_US
bordeaux.hal.laboratoriesNutrition et Neurobiologie intégréeen_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcepubmed
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Translational%20Psychiatry&rft.date=2024-03-01&rft.volume=14&rft.issue=1&rft.spage=131&rft.epage=131&rft.eissn=2158-3188&rft.issn=2158-3188&rft.au=SPANO,%20Luana&MARIE-CLAIRE,%20Cynthia&GODIN,%20Oph%C3%A9lia&LEBRAS,%20Apolline&COURTIN,%20Cindie&rft.genre=article


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