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dc.rights.licenseopenen_US
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorCOURTECUISSE, Elise
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorBOURASSEAU, Sylvain
hal.structure.identifierNorwegian University of Science and Technology [Trondheim] [NTNU]
dc.contributor.authorCHRISTENSEN, Bjørn E.
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorSCHATZ, Christophe
dc.date.accessioned2024-09-03T07:59:03Z
dc.date.available2024-09-03T07:59:03Z
dc.date.issued2024-12-01
dc.identifier.issn0144-8617en_US
dc.identifier.urioai:crossref.org:10.1016/j.carbpol.2024.122576
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/201400
dc.description.abstractEnDihydrazide (ADH) and dioxyamine (PDHA) were assessed for their efficacy in coupling chitosan and dextran via their reducing ends. Initially, the end-functionalization of the individual polysaccharide blocks was investigated. Under non-reducing conditions, chitosan with a 2,5-anhydro-D-mannose unit at its reducing end exhibited high reactivity with both PDHA and ADH. Dextran, with a normal reducing end, showed superior reactivity with PDHA compared to ADH, although complete conversion with ADH could be achieved under reductive conditions with NaBH3CN. Importantly, the oxime bond in PDHA conjugates exhibited greater stability against hydrolysis compared to the hydrazone bond in ADH conjugates. The optimal block coupling method consisted in reacting chitosan with an excess of dextran pre-functionalized with PDHA. The copolysaccharides could be synthesized in high yields under both reducing and non-reducing conditions. This methodology was applied to relatively long polysaccharide blocks with molecular weight up to 14,000 g/mol for chitosan and up to 40,000 g/mol for dextran. Surprisingly, block copolysaccharides did not self-assemble at neutral or basic pH; rather, they precipitated due to hydrogen bonding between neutralized amino groups of chitosan. However, nanoparticles could be obtained through a nanoprecipitation approach.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.sourcecrossref
dc.subject.enChitosan
dc.subject.enDextran
dc.subject.enHydrazone
dc.subject.enOxime
dc.subject.enConjugate
dc.subject.enBlock copolymer
dc.title.enSynthesis of linear chitosan-block-dextran copolysaccharides with dihydrazide and dioxyamine linkers
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.carbpol.2024.122576en_US
dc.subject.halChimie/Polymèresen_US
bordeaux.journalCarbohydrate Polymersen_US
bordeaux.page122576en_US
bordeaux.volume345en_US
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcedissemin
hal.identifierhal-04684791
hal.version1
hal.date.transferred2024-09-03T07:59:06Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcedissemin
dc.rights.ccCC BY-NC-SAen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Carbohydrate%20Polymers&rft.date=2024-12-01&rft.volume=345&rft.spage=122576&rft.epage=122576&rft.eissn=0144-8617&rft.issn=0144-8617&rft.au=COURTECUISSE,%20Elise&BOURASSEAU,%20Sylvain&CHRISTENSEN,%20Bj%C3%B8rn%20E.&SCHATZ,%20Christophe&rft.genre=article


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