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Effect of Bioactive Glasses and Basic Fibroblast Growth Factor on Dental Pulp Cells

dc.rights.licenseopenen_US
dc.contributor.authorWASHIO, A.
dc.contributor.authorKÉROURÉDAN, O.
dc.contributor.authorTABATA, Y.
dc.contributor.authorKOKABU, S.
dc.contributor.authorKITAMURA, C.
dc.date.accessioned2024-06-03T08:48:15Z
dc.date.available2024-06-03T08:48:15Z
dc.date.issued2023-12
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/200207
dc.description.abstractEnIdeal regeneration of hard tissue and dental pulp has been reported with the use of a combination of bioactive glass and basic fibroblast growth factor (bFGF). However, no previous study has investigated the molecular mechanisms underlying the processes induced by this combination in dental pulp cells. This study aimed to examine the cellular phenotype and transcriptional changes induced by the combination of bioactive glass solution (BG) and bFGF in dental pulp cells using phase-contrast microscopy, a cell counting kit-8 assay, alkaline phosphatase staining, and RNA sequence analysis. bFGF induced elongation of the cell process and increased the number of cells. Whereas BG did not increase ALP activity, it induced extracellular matrix-related genes in the dental pulp. In addition, the combination of BG and bFGF induces gliogenesis-related genes in the nervous system. This is to say, bFGF increased the viability of dental pulp cells, bioactive glass induced odontogenesis, and a dual stimulation with bioactive glass and bFGF induced the wound healing of the nerve system in the dental pulp. Taken together, bioactive glass and bFGF may be useful for the regeneration of the dentin-pulp complex. © 2023 by the authors.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.title.enEffect of Bioactive Glasses and Basic Fibroblast Growth Factor on Dental Pulp Cells
dc.typeArticle de revueen_US
dc.identifier.doi10.3390/jfb14120568en_US
dc.subject.halSciences du Vivant [q-bio]en_US
bordeaux.journalJournal of Functional Biomaterialsen_US
bordeaux.volume14en_US
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026en_US
bordeaux.issue12en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCHU de Bordeauxen_US
bordeaux.institutionInstitut Bergoniéen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
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hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccCC BYen_US
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