A second update on mapping the human genetic architecture of COVID-19
| dc.rights.license | open | en_US |
| dc.contributor.author | INITIATIVE, Covid- Host Genetics | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DEBETTE, Stephanie | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | TREGOUET, David-Alexandre | |
| dc.date.accessioned | 2024-05-21T07:46:56Z | |
| dc.date.available | 2024-05-21T07:46:56Z | |
| dc.date.issued | 2023-09-01 | |
| dc.identifier.issn | 1476-4687 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/199944 | |
| dc.description.abstractEn | Investigating the role of host genetic factors in COVID-19 severity and susceptibility can inform our understanding of the underlying biological mechanisms that influence adverse outcomes and drug development 1,2 . Here we present a second updated genome-wide association study (GWAS) on COVID-19 severity and infection susceptibility to SARS-CoV-2 from the COVID-19 Host Genetic Initiative (data release 7). We performed a meta-analysis of up to 219,692 cases and over 3 million controls, identifying 51 distinct genome-wide significant loci—adding 28 loci from the previous data release 2 . The increased number of candidate genes at the identified loci helped to map three major biological pathways involved in susceptibility and severity: viral entry, airway defense in mucus, and type I interferon. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.title.en | A second update on mapping the human genetic architecture of COVID-19 | |
| dc.title.alternative | Nature | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1038/s41586-023-06355-3 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 37674002 | en_US |
| bordeaux.journal | Nature | en_US |
| bordeaux.page | E7-E26 | en_US |
| bordeaux.volume | 621 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 7977 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | ELEANOR_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature&rft.date=2023-09-01&rft.volume=621&rft.issue=7977&rft.spage=E7-E26&rft.epage=E7-E26&rft.eissn=1476-4687&rft.issn=1476-4687&rft.au=INITIATIVE,%20Covid-%20Host%20Genetics&DEBETTE,%20Stephanie&TREGOUET,%20David-Alexandre&rft.genre=article |
