INITIATIVE, Covid- Host Genetics; DEBETTE, Stephanie; TREGOUET, David-Alexandre

doi:10.1038/s41586-023-06355-3

DEBETTE, Stephanie
Bordeaux population health [BPH]

TREGOUET, David-Alexandre

Bordeaux population health [BPH]

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Ce document a été publié dans

Nature. 2023-09-01, vol. 621, n° 7977, p. E7-E26

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Investigating the role of host genetic factors in COVID-19 severity and susceptibility can inform our understanding of the underlying biological mechanisms that influence adverse outcomes and drug development 1,2 . Here we present a second updated genome-wide association study (GWAS) on COVID-19 severity and infection susceptibility to SARS-CoV-2 from the COVID-19 Host Genetic Initiative (data release 7). We performed a meta-analysis of up to 219,692 cases and over 3 million controls, identifying 51 distinct genome-wide significant loci—adding 28 loci from the previous data release 2 . The increased number of candidate genes at the identified loci helped to map three major biological pathways involved in susceptibility and severity: viral entry, airway defense in mucus, and type I interferon.< Réduire

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https://oskar-bordeaux.fr/handle/20.500.12278/199944

DOI

http://dx.doi.org/10.1038/s41586-023-06355-3

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Bordeaux Population Health Research Center (BPH) - UMR 1219

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A second update on mapping the human genetic architecture of COVID-19

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