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Oyster transcriptome response to Alexandrium exposure is related to saxitoxin load and characterized by disrupted digestion, energy balance, and calcium and sodium signaling

dc.rights.licenseopenen_US
hal.structure.identifierLaboratoire des Sciences de l'Environnement Marin (LEMAR) [LEMAR]
hal.structure.identifierInstitut Français de Recherche pour l'Exploitation de la Mer [IFREMER]
dc.contributor.authorMAT, Audrey
hal.structure.identifierPlateforme Bio-Informatique - Génotoul
dc.contributor.authorKLOPP, Christophe
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorPAYTON, Laura
hal.structure.identifierGénome et Transcriptome - Plateforme Génomique [ GeT-PlaGe]
dc.contributor.authorJEZIORSKI, Céline
hal.structure.identifierLaboratoire des Sciences de l'Environnement Marin (LEMAR) [LEMAR]
hal.structure.identifierInstitut Français de Recherche pour l'Exploitation de la Mer [IFREMER]
dc.contributor.authorCHALOPIN, Morgane
hal.structure.identifierInstitut Français de Recherche pour l'Exploitation de la Mer [IFREMER]
dc.contributor.authorAMZIL, Zouher
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorTRAN, Damien
hal.structure.identifierNOAA National Marine Fisheries Service [NMFS]
dc.contributor.authorWIKFORS, Gary
hal.structure.identifierLaboratoire des Sciences de l'Environnement Marin (LEMAR) [LEMAR]
dc.contributor.authorHEGARET, Helene
hal.structure.identifierLaboratoire des Sciences de l'Environnement Marin (LEMAR) [LEMAR]
dc.contributor.authorSOUDANT, Philippe
hal.structure.identifierLaboratoire des Sciences de l'Environnement Marin (LEMAR) [LEMAR]
hal.structure.identifierInstitut Français de Recherche pour l'Exploitation de la Mer [IFREMER]
dc.contributor.authorHUVET, Arnaud
hal.structure.identifierLaboratoire des Sciences de l'Environnement Marin (LEMAR) [LEMAR]
dc.contributor.authorFABIOUX, Caroline
dc.date.accessioned2024-05-06T08:13:52Z
dc.date.available2024-05-06T08:13:52Z
dc.date.issued2018-06
dc.identifier.issn0166-445Xen_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/199628
dc.description.abstractEnHarmful Algal Blooms are worldwide occurrences that can cause poisoning in human seafood consumers as well as mortality and sublethal effets in wildlife, propagating economic losses. One of the most widespread toxigenic microalgal taxa is the dinoflagellate Genus Alexandrium, that includes species producing neurotoxins referred to as PST (Paralytic Shellfish Toxins). Blooms cause shellfish harvest restrictions to protect human consumers from accumulated toxins. Large inter-individual variability in toxin load within an exposed bivalve population complicates monitoring of shellfish toxicity for ecology and human health regulation. To decipher the physiological pathways involved in the bivalve response to PST, we explored the whole transcriptome of the digestive gland of the Pacific oyster Crassostrea gigas fed experimentally with a toxic Alexandrium minutum culture. The largest differences in transcript abundance were between oysters with contrasting toxin loads (1098 transcripts), rather than between exposed and non-exposed oysters (16 transcripts), emphasizing the importance of toxin load in oyster response to toxic dinoflagellates. Additionally, penalized regressions, innovative in this field, modeled accurately toxin load based upon only 70 transcripts. Transcriptomic differences between oysters with contrasting PST burdens revealed a limited suite of metabolic pathways affected, including ion channels, neuromuscular communication, and digestion, all of which are interconnected and linked to sodium and calcium exchanges. Carbohydrate metabolism, unconsidered previously in studies of harmful algal effects on shellfish, was also highlighted, suggesting energy challenge in oysters with high toxin loads. Associations between toxin load, genotype, and mRNA levels were revealed that open new doors for genetic studies identifying genetically-based low toxin accumulation.
dc.description.sponsorshipDe la caractérisation des déterminants de l'accumulation des toxines paralysantes (PST) chez l'huître (Crassostrea gigas) au risque sanitaire pour l'homme dans son contexte sociétal - ANR-13-CESA-0019en_US
dc.language.isoENen_US
dc.subject.enTranscriptomic
dc.subject.enIons channels
dc.subject.enACL
dc.subject.enParalytic shellfish toxins
dc.subject.enElastic-net regression
dc.title.enOyster transcriptome response to Alexandrium exposure is related to saxitoxin load and characterized by disrupted digestion, energy balance, and calcium and sodium signaling
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.aquatox.2018.03.030en_US
dc.subject.halSciences de l'environnementen_US
dc.subject.halSciences du Vivant [q-bio]en_US
dc.subject.halSciences du Vivant [q-bio]/Ecologie, Environnementen_US
dc.subject.halSciences de l'environnement/Biodiversité et Ecologieen_US
bordeaux.journalAquatic Toxicologyen_US
bordeaux.page127-137en_US
bordeaux.volume199en_US
bordeaux.hal.laboratoriesEPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.teamEAen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-02324597
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Aquatic%20Toxicology&rft.date=2018-06&rft.volume=199&rft.spage=127-137&rft.epage=127-137&rft.eissn=0166-445X&rft.issn=0166-445X&rft.au=MAT,%20Audrey&KLOPP,%20Christophe&PAYTON,%20Laura&JEZIORSKI,%20C%C3%A9line&CHALOPIN,%20Morgane&rft.genre=article


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