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Methods for the identification and characterization of extracellular vesicles in cardiovascular studiesfrom exosomes to microvesicles

dc.rights.licenseopenen_US
dc.contributor.authorDAVIDSON, Sean
dc.contributor.authorBOULANGER, Chantal
dc.contributor.authorAIKAWA, Elena
dc.contributor.authorBADIMON, Lina
dc.contributor.authorBARILE, Lucio
dc.contributor.authorBINDER, Christoph
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorBRISSON, Alain
dc.contributor.authorBUZAS, Edit
dc.contributor.authorEMANUELI, Costanza
dc.contributor.authorJANSEN, Felix
dc.contributor.authorKATSUR, Miroslava
dc.contributor.authorLACROIX, Romaric
dc.contributor.authorLIM, Sai
dc.contributor.authorMACKMAN, Nigel
dc.contributor.authorMAYR, Manuel
dc.contributor.authorMENASCHE, Philippe
dc.contributor.authorNIEUWLAND, Rienk
dc.contributor.authorSAHOO, Susmita
dc.contributor.authorTAKOV, Kaloyan
dc.contributor.authorTHUM, Thomas
dc.contributor.authorVADER, Pieter
dc.contributor.authorWAUBEN, Marca
dc.contributor.authorWITWER, Kenneth
dc.contributor.authorSLUIJTER, Joost
dc.date.accessioned2024-05-03T07:39:07Z
dc.date.available2024-05-03T07:39:07Z
dc.date.issued2023
dc.identifier.issn0008-6363en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/199585
dc.description.abstractEnExtracellular vesicles (EVs) are nanosized vesicles with a lipid bilayer that are released from cells of the cardiovascular system, and are considered important mediators of intercellular and extracellular communication. Two types of EV of particular interest are exosomes and microvesicles, which have been identified in all tissue and body fluids and carry a variety of molecules including RNAs, proteins, and lipids. EVs have potential for use in the diagnosis and prognosis of cardiovascular diseases and as new therapeutic agents, particularly in the setting of myocardial infarction and heart failure. Despite their promise, technical challenges related to their small size make it challenging to accurately identify and characterize them, and to study EV-mediated processes. Here, we aim to provide the reader with an overview of the techniques and technologies available for the separation and characterization of EVs from different sources. Methods for determining the protein, RNA and lipid content of EVs are discussed. The aim of this document is to provide guidance on critical methodological issues and highlight key points for consideration for the investigation of EVs in cardiovascular studies.
dc.description.sponsorshipARN non codant d'origine cardiomyocytaire et remodelage cardiaque post-ischémique - ANR-16-CE92-0032en_US
dc.language.isoENen_US
dc.subject.encardiovascular diseases
dc.subject.enexosomes
dc.subject.enextracellular vesicles
dc.subject.enmicro vesicles
dc.subject.enplasma
dc.title.enMethods for the identification and characterization of extracellular vesicles in cardiovascular studiesfrom exosomes to microvesicles
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/cvr/cvac031en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaireen_US
bordeaux.journalCardiovascular Researchen_US
bordeaux.page45-63en_US
bordeaux.volume1149en_US
bordeaux.hal.laboratoriesCBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierinserm-03620308
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
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