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Naproxen-bipyridine cocrystallization assisted by pressurized carbon dioxide

dc.rights.licenseopenen_US
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorERCICEK, Fatma
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorHARSCOAT-SCHIAVO, Christelle
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorLAYRISSE, Patrick
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorMARCHIVIE, Mathieu
dc.contributor.authorCARTIGNY, Yohann
dc.contributor.authorBRANDEL, Clement
dc.contributor.authorTASSAING, Thierry
dc.contributor.authorCONRAD, Max
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorMARRE, Samuel
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorSUBRA-PATERNAULT, Pascale
dc.date.accessioned2024-04-30T10:12:35Z
dc.date.available2024-04-30T10:12:35Z
dc.date.issued2023
dc.identifier.issn0896-8446en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/199532
dc.description.abstractEnCocrystals of S-naproxen (S-NPX) or RS-naproxen (RS-NPX) and 4,4′bipyridine (BiPY) were prepared by the Gaseous Anti Solvent (GAS) method using CO2 as antisolvent. S-NPX and BiPY cocrystals were also produced by Cocrystallization with Supercritical Solvent (CSS) using CO2 as a solvent though leading to mixtures of cocrystals and homocrystals. Hydrogen-bond networks and stoichiometries of produced cocrystals were identical whatever the mode of preparation (evaporation, grinding and CO2-assisted processes) and matched those already described in literature: S-NPX2:BiPY1 and RS-NPX2:BiPY1. The effects of the NPX:BiPY molar ratio and of the processing conditions were investigated. By GAS, an excess of BiPY in the initial processed mixture was mandatory to produce pure S-NPX2:BiPY1 cocrystals whereas pure RS-NPX2:BiPY1 cocrystals were identically produced from mixtures of 2:2 and 2:1 NPX:BiPY initial ratio. No enrichment of the product in any of the naproxen enantiomer was reached, even when mixtures of S- + RS-NPX were coprocessed with bipyridine.
dc.description.sponsorshipApport du CO2 dans le contrôle de phase cristalline - ANR-18-CE07-0047en_US
dc.language.isoENen_US
dc.subject.enCocrystal
dc.subject.enCO2
dc.subject.encrystallization
dc.subject.ennaproxen
dc.subject.enbipyridine
dc.subject.enantisolvent
dc.title.enNaproxen-bipyridine cocrystallization assisted by pressurized carbon dioxide
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.supflu.2023.105976en_US
dc.subject.halChimie/Matériauxen_US
dc.subject.halSciences du Vivant [q-bio]/Sciences pharmaceutiques/Pharmacie galéniqueen_US
bordeaux.journalJournal of Supercritical Fluidsen_US
bordeaux.page105976en_US
bordeaux.volume200en_US
bordeaux.hal.laboratoriesCBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-04098643
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Supercritical%20Fluids&rft.date=2023&rft.volume=200&rft.spage=105976&rft.epage=105976&rft.eissn=0896-8446&rft.issn=0896-8446&rft.au=ERCICEK,%20Fatma&HARSCOAT-SCHIAVO,%20Christelle&LAYRISSE,%20Patrick&MARCHIVIE,%20Mathieu&CARTIGNY,%20Yohann&rft.genre=article


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