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High‐Affinity Hybridization of Complementary Aromatic Oligoamide Strands in Water

dc.rights.licenseopenen_US
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorKOEHLER, Victor
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorBRUSCHERA, Gabrielle
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorMERLET, Eric
dc.contributor.authorMANDAL, Pradeep
dc.contributor.authorMORVAN, Estelle
dc.contributor.authorROSU, Frederic
dc.contributor.authorDOUAT, Celine
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorFISCHER, Lucile
dc.contributor.authorHUC, Ivan
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorFERRAND, Yann
dc.date.accessioned2024-04-30T09:34:47Z
dc.date.available2024-04-30T09:34:47Z
dc.date.issued2023
dc.identifier.issn1433-7851en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/199529
dc.description.abstractEnWe prepared a series of water‐soluble aromatic oligoamide sequences all composed of a segment prone to form a single helix and a segment prone to dimerize into a double helix. These sequences exclusively assemble as antiparallel duplexes. The modification of the duplex inner rim by varying the nature of the substituents borne by the aromatic monomers allowed us to identify sequences that can hybridize by combining two chemically different strands, with high affinity and complete selectivity in water. X‐ray crystallography confirmed the expected antiparallel configuration of the duplexes whereas NMR spectroscopy and mass spectrometry allowed us to assess precisely the extent of the hybridization. The hybridization kinetics of the aromatic strands was shown to depend on both the nature of the substituents responsible for strand complementarity and the length of the aromatic strand. These results highlight the great potential of aromatic hetero‐duplexes as a tool to construct non‐symmetrical dynamic supramolecular assemblies.
dc.description.sponsorshipAssemblage dynamique de foldamères oligoamides aromatiques pour la stabilisation d'interactions protéine-protéine - ANR-19-CE07-0034en_US
dc.language.isoENen_US
dc.title.enHigh‐Affinity Hybridization of Complementary Aromatic Oligoamide Strands in Water
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/anie.202311639en_US
dc.subject.halChimieen_US
bordeaux.journalAngewandte Chemie International Editionen_US
bordeaux.hal.laboratoriesCBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-04234549
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Angewandte%20Chemie%20International%20Edition&rft.date=2023&rft.eissn=1433-7851&rft.issn=1433-7851&rft.au=KOEHLER,%20Victor&BRUSCHERA,%20Gabrielle&MERLET,%20Eric&MANDAL,%20Pradeep&MORVAN,%20Estelle&rft.genre=article


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