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Membrane plasticity induced by myo-inositol derived archaeal lipids: chemical synthesis and biophysical characterization

dc.rights.licenseopenen_US
dc.contributor.authorRUIZ, Johal
dc.contributor.authorLORICCO, Josephine
dc.contributor.authorSOULERE, Laurent
dc.contributor.authorSALVADOR CASTELL, Marta
hal.structure.identifierInstitut Européen de Chimie et Biologie [IECB]
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorGRELARD, Axelle
hal.structure.identifierInstitut Européen de Chimie et Biologie [IECB]
dc.contributor.authorKAUFFMANN, Brice
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
hal.structure.identifierInstitut Européen de Chimie et Biologie [IECB]
dc.contributor.authorDUFOURC, Erick
dc.contributor.authorDEME, Bruno
dc.contributor.authorPOPOWYCZ, Florence
dc.contributor.authorPETERS, Judith
dc.date.accessioned2024-04-30T09:17:12Z
dc.date.available2024-04-30T09:17:12Z
dc.date.issued2023
dc.identifier.issn1463-9076en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/199527
dc.description.abstractEnArchaeal membrane lipids have specific structures that allow Archaea to withstand extreme conditions of temperature and pressure. In order to understand the molecular parameters that govern such resistance, the synthesis of 1,2-di-O-phytanyl-sn-glycero-3-phosphoinositol (DoPhPI), an archaeal lipid derived from myo-inositol, is reported. Benzyl protected myo-inositol was first prepared and then transformed to phosphodiester derivatives using a phosphoramidite based-coupling reaction with archaeol. Aqueous dispersions of DoPhPI alone or mixed with DoPhPC can be extruded and form small unilamellar vesicles, as detected by DLS. Neutron, SAXS, and solid-state NMR demonstrated that the water dispersions could form a lamellar phase at room temperature that then evolves into cubic and hexagonal phases with increasing temperature. Phytanyl chains were also found to impart remarkable and nearly constant dynamics to the bilayer over wide temperature ranges. All these new properties of archaeal lipids are proposed as providers of plasticity and thus means for the archaeal membrane to resist extreme conditions.
dc.language.isoENen_US
dc.subject.enMAGNETIC-RESONANCE
dc.subject.enSPECTROMETER IN15
dc.subject.enPHASE
dc.subject.enBILAYERS
dc.subject.enPECTROSCOPY
dc.subject.enTEMPERATURE
dc.subject.enPRESSURE
dc.subject.enSYSTEMS
dc.subject.enORDER
dc.subject.enNMR
dc.title.enMembrane plasticity induced by myo-inositol derived archaeal lipids: chemical synthesis and biophysical characterization
dc.typeArticle de revueen_US
dc.identifier.doi10.1039/d3cp01646cen_US
dc.subject.halChimieen_US
dc.subject.halSciences du Vivant [q-bio]en_US
dc.subject.halSciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Biophysiqueen_US
bordeaux.journalPhysical Chemistry Chemical Physicsen_US
bordeaux.page16273 - 16287en_US
bordeaux.volume25en_US
bordeaux.hal.laboratoriesCBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248en_US
bordeaux.issue24en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-04391247
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Physical%20Chemistry%20Chemical%20Physics&rft.date=2023&rft.volume=25&rft.issue=24&rft.spage=16273%20-%2016287&rft.epage=16273%20-%2016287&rft.eissn=1463-9076&rft.issn=1463-9076&rft.au=RUIZ,%20Johal&LORICCO,%20Josephine&SOULERE,%20Laurent&SALVADOR%20CASTELL,%20Marta&GRELARD,%20Axelle&rft.genre=article


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