The impact of lipid polyunsaturation on the physical and mechanical properties of lipid membranes
| dc.rights.license | open | en_US |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | BACCOUCH, Rim | |
| dc.contributor.author | SHI, Yarong | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | VERNAY, Emilie | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | MATHELIE-GUINLET, Marion | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | TAIB-MAAMAR, Nada | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | VILLETTE, Sandrine | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | FEUILLIE, Cecile | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | RASCOL, Estelle | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | NUSS, Philippe | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | LECOMTE, Sophie | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | MOLINARI, Michael | |
| dc.contributor.author | STANEVA, Galya | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | ALVES, Isabel | |
| dc.date.accessioned | 2024-04-24T10:05:32Z | |
| dc.date.available | 2024-04-24T10:05:32Z | |
| dc.date.issued | 2023-02 | |
| dc.identifier.issn | 0005-2736 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/199305 | |
| dc.description.abstractEn | The lipid composition of cellular membranes and the balance between the different lipid components can be impacted by aging, certain pathologies, specific diets and other factors. This is the case in a subgroup of individuals with psychiatric disorders, such as schizophrenia, where cell membranes of patients have been shown to be deprived in polyunsaturated fatty acids (PUFAs), not only in brain areas where the target receptors are expressed but also in peripheral tissues. This PUFA deprivation thus represents a biomarker of such disorders that might impact not only the interaction of antipsychotic medications with these membranes but also the activation and signaling of the targeted receptors embedded in the lipid membrane. Therefore, it is crucial to understand how PUFAs levels alterations modulate the different physical properties of membranes.In this paper, several biophysical approaches were combined (Laurdan fluorescence spectroscopy, atomic force microscopy, differential scanning calorimetry, molecular modeling) to characterize membrane properties such as fluidity, elasticity and thickness in PUFA-enriched cell membranes and lipid model systems reflecting the PUFA imbalance observed in some diseases. The impact of both the number of unsaturations and their position along the chain on the above properties was investigated. Briefly, data revealed that PUFA presence in membranes increases membrane fluidity, elasticity and flexibility and decreases its thickness and order parameter. Both the level of unsaturation and their position affect these membrane properties. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | polyunsaturated fatty acids | |
| dc.subject.en | lipid membrane physico-chemical properties | |
| dc.subject.en | fluidity | |
| dc.subject.en | lipid phase transition temperature | |
| dc.subject.en | thickness | |
| dc.title.en | The impact of lipid polyunsaturation on the physical and mechanical properties of lipid membranes | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.bbamem.2022.184084 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Biophysique | en_US |
| bordeaux.journal | Biochimica et Biophysica Acta:Biomembranes | en_US |
| bordeaux.page | 184084 | en_US |
| bordeaux.volume | 1865 | en_US |
| bordeaux.hal.laboratories | CBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248 | en_US |
| bordeaux.issue | 2 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | Bordeaux INP | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | hal | |
| hal.identifier | hal-03864167 | |
| hal.version | 1 | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| workflow.import.source | hal | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biochimica%20et%20Biophysica%20Acta:Biomembranes&rft.date=2023-02&rft.volume=1865&rft.issue=2&rft.spage=184084&rft.epage=184084&rft.eissn=0005-2736&rft.issn=0005-2736&rft.au=BACCOUCH,%20Rim&SHI,%20Yarong&VERNAY,%20Emilie&MATHELIE-GUINLET,%20Marion&TAIB-MAAMAR,%20Nada&rft.genre=article |
Files in this item
| Files | Size | Format | View |
|---|---|---|---|
|
There are no files associated with this item. |
|||