Mostrar el registro sencillo del ítem

Shigella IpaA mediates actin bundling through diffusible vinculin oligomers with activation imprint

dc.rights.licenseopenen_US
hal.structure.identifierCentre interdisciplinaire de recherche en biologie [CIRB]
hal.structure.identifierLabex MemoLife
dc.contributor.authorVALENCIA-GALLARDO, Cesar
hal.structure.identifierCentre interdisciplinaire de recherche en biologie [CIRB]
hal.structure.identifierLaboratoire de biologie et pharmacologie appliquée [LBPA]
dc.contributor.authorAGUILAR-SALVADOR, Daniel-Isui
hal.structure.identifierCentre interdisciplinaire de recherche en biologie [CIRB]
hal.structure.identifierLaboratoire de biologie et pharmacologie appliquée [LBPA]
dc.contributor.authorKHAKZAD, Hamed
hal.structure.identifierCentre interdisciplinaire de recherche en biologie [CIRB]
hal.structure.identifierLaboratoire de biologie et pharmacologie appliquée [LBPA]
hal.structure.identifierInstitut de Biologie Intégrative de la Cellule [I2BC]
dc.contributor.authorCOCOM-CHAN, Benjamin
hal.structure.identifierLaboratoire de Chimie des Processus Biologiques [LCPB]
dc.contributor.authorBOU-NADER, Charles
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorVELOURS, Christophe
hal.structure.identifierInstitut de Biologie Intégrative de la Cellule [I2BC]
dc.contributor.authorZARROUK, Yosra
hal.structure.identifierInstitut de Biologie Intégrative de la Cellule [I2BC]
dc.contributor.authorLE CLAINCHE, Christophe
hal.structure.identifierSpectrométrie de Masse pour la Biologie – Mass Spectrometry for Biology [UTechS MSBio]
dc.contributor.authorMALOSSE, Christian
hal.structure.identifierSpectrométrie de Masse pour la Biologie – Mass Spectrometry for Biology [UTechS MSBio]
dc.contributor.authorLIMA, Diogo Borges
hal.structure.identifierCentre interdisciplinaire de recherche en biologie [CIRB]
dc.contributor.authorQUENECH’DU, Nicole
hal.structure.identifierCentre interdisciplinaire de recherche en biologie [CIRB]
dc.contributor.authorMAZHAR, Bilal
hal.structure.identifierLaboratoire de biologie et pharmacologie appliquée [LBPA]
dc.contributor.authorESSID, Sami
hal.structure.identifierLaboratoire de Chimie des Processus Biologiques [LCPB]
hal.structure.identifierCollège de France - Chaire Chimie des processus biologiques
dc.contributor.authorFONTECAVE, Marc
hal.structure.identifierMatière et Systèmes Complexes [MSC]
dc.contributor.authorASNACIOS, Atef
hal.structure.identifierSpectrométrie de Masse pour la Biologie – Mass Spectrometry for Biology [UTechS MSBio]
dc.contributor.authorCHAMOT-ROOKE, Julia
hal.structure.identifierLund University
dc.contributor.authorMALMSTRÖM, Lars
hal.structure.identifierCentre interdisciplinaire de recherche en biologie [CIRB]
hal.structure.identifierLaboratoire de biologie et pharmacologie appliquée [LBPA]
hal.structure.identifierInstitut de Biologie Intégrative de la Cellule [I2BC]
dc.contributor.authorTRAN VAN NHIEU, Guy
dc.date.accessioned2024-04-24T09:34:30Z
dc.date.available2024-04-24T09:34:30Z
dc.date.issued2023-04
dc.identifier.issn2211-1247en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/199299
dc.description.abstractEnUpon activation, vinculin reinforces cytoskeletal anchorage during cell adhesion. Activating ligands classically disrupt intramolecular interactions between the vinculin head and tail domains that bind to actin filaments. Here, we show that Shigella IpaA triggers major allosteric changes in the head domain, leading to vinculin homo-oligomerization. Through the cooperative binding of its three vinculin-binding sites (VBSs), IpaA induces a striking reorientation of the D1 and D2 head subdomains associated with vinculin oligomerization. IpaA thus acts as a catalyst producing vinculin clusters that bundle actin at a distance from the activation site and trigger the formation of highly stable adhesions resisting the action of actin relaxing drugs. Unlike canonical activation, vinculin homo-oligomers induced by IpaA appear to keep a persistent imprint of the activated state in addition to their bundling activity, accounting for stable cell adhesion independent of force transduction and relevant to bacterial invasion.
dc.description.sponsorshipMemory in living systems: an integrated approachen_US
dc.language.isoENen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/
dc.subject.enShigella
dc.subject.eninvasion
dc.subject.envinculin
dc.subject.enadhesion
dc.subject.enactin
dc.subject.enbundling
dc.title.enShigella IpaA mediates actin bundling through diffusible vinculin oligomers with activation imprint
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.celrep.2023.112405en_US
dc.subject.halSciences du Vivant [q-bio]en_US
dc.identifier.pubmed37071535en_US
bordeaux.journalCell Reportsen_US
bordeaux.page112405en_US
bordeaux.volume42en_US
bordeaux.hal.laboratoriesMFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234en_US
bordeaux.issue4en_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-04238555
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cell%20Reports&rft.date=2023-04&rft.volume=42&rft.issue=4&rft.spage=112405&rft.epage=112405&rft.eissn=2211-1247&rft.issn=2211-1247&rft.au=VALENCIA-GALLARDO,%20Cesar&AGUILAR-SALVADOR,%20Daniel-Isui&KHAKZAD,%20Hamed&COCOM-CHAN,%20Benjamin&BOU-NADER,%20Charles&rft.genre=article


Archivos en el ítem

Thumbnail
Nombre:
MFP_Cell_Reports_2023_Valencia ...
Tamaño:
5.545Mb
Formato:
PDF
Ver/Abrir

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem