Annexin‐A5 and annexin‐A6 silencing prevents metastasis of breast cancer cells in zebrafish
| dc.rights.license | open | en_US |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | GOUNOU, Celine | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | BOUVET, Flora | |
| hal.structure.identifier | BoRdeaux Institute in onCology [Inserm U1312 - BRIC] | |
| dc.contributor.author | LIET, Benjamin | |
| hal.structure.identifier | BoRdeaux Institute in onCology [Inserm U1312 - BRIC] | |
| dc.contributor.author | PROUZET-MAULEON, Valerie | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | D'AGATA, Lena | |
| hal.structure.identifier | Laboratoire Ondes et Matière d'Aquitaine [LOMA] | |
| dc.contributor.author | HARTE, Etienne | |
| hal.structure.identifier | Laboratoire Ondes et Matière d'Aquitaine [LOMA] | |
| dc.contributor.author | ARGOUL, Francoise | |
| hal.structure.identifier | BoRdeaux Institute in onCology [Inserm U1312 - BRIC] | |
| dc.contributor.author | SIEGFRIED, Geraldine | |
| hal.structure.identifier | BoRdeaux Institute in onCology [Inserm U1312 - BRIC] | |
| dc.contributor.author | IGGO, Richard | |
| hal.structure.identifier | BoRdeaux Institute in onCology [Inserm U1312 - BRIC] | |
| dc.contributor.author | KHATIB, Abdel‐majid | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | BOUTER, Anthony | |
| dc.date.accessioned | 2024-04-24T09:00:50Z | |
| dc.date.available | 2024-04-24T09:00:50Z | |
| dc.date.issued | 2023-04-07 | |
| dc.identifier.issn | 0248-4900 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/199293 | |
| dc.description.abstractEn | Abstract Background Information During tumor invasion and metastasis processes, cancer cells are exposed to major compressive and shearing forces, due to their migration through extracellular matrix, dense cell areas, and complex fluids, which may lead to numerous plasma membrane damages. Cancer cells may survive to these mechanical stresses thanks to an efficient membrane repair machinery. Consequently, this machinery may constitute a relevant target to inhibit cancer cell dissemination. Results We show here that annexin‐A5 (ANXA5) and ANXA6 participate in membrane repair of MDA‐MB‐231 cells, a highly invasive triple‐negative breast cancer cell line. These crucial components of the membrane repair machinery are substantially expressed in breast cancer cells in correlation with their invasive properties. In addition, high expression of ANXA5 and ANXA6 predict poor prognosis in high‐grade lung, gastric, and breast cancers. In zebrafish, the genetic inhibition of ANXA5 and ANXA6 leads to drastic reduction of tumor cell dissemination. Conclusion We conclude that the inhibition of ANXA5 and ANXA6 prevents membrane repair in cancer cells, which are thus unable to survive to membrane damage during metastasis. Significance This result opens a new therapeutic strategy based on targeting membrane repair machinery to inhibit tumor invasion and metastasis. | |
| dc.language.iso | EN | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by/ | |
| dc.title.en | Annexin‐A5 and annexin‐A6 silencing prevents metastasis of breast cancer cells in zebrafish | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1111/boc.202200110 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio] | en_US |
| dc.subject.hal | Physique [physics] | en_US |
| bordeaux.journal | Biology of the Cell | en_US |
| bordeaux.volume | 115 | en_US |
| bordeaux.hal.laboratories | CBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248 | en_US |
| bordeaux.issue | 6 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | Bordeaux INP | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | hal | |
| hal.identifier | hal-04305236 | |
| hal.version | 1 | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| workflow.import.source | hal | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biology%20of%20the%20Cell&rft.date=2023-04-07&rft.volume=115&rft.issue=6&rft.eissn=0248-4900&rft.issn=0248-4900&rft.au=GOUNOU,%20Celine&BOUVET,%20Flora&LIET,%20Benjamin&PROUZET-MAULEON,%20Valerie&D'AGATA,%20Lena&rft.genre=article |
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