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Kidney Function Decline and Serious Adverse Drug Reactions in Patients With CKD

dc.rights.licenseopenen_US
hal.structure.identifierCHU Amiens-Picardie
hal.structure.identifierMécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 [MP3CV]
dc.contributor.authorLAVILLE, Solène
hal.structure.identifierCHU Amiens-Picardie
hal.structure.identifierMécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 [MP3CV]
dc.contributor.authorGRAS-CHAMPEL, Valérie
hal.structure.identifierUniversité de Lille
hal.structure.identifierCentre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
dc.contributor.authorHAMROUN, Aghilès
hal.structure.identifierCHU Amiens-Picardie
dc.contributor.authorMORAGNY, Julien
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
dc.contributor.authorLAMBERT, Oriane
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
hal.structure.identifierUniversité de Versailles Saint-Quentin-en-Yvelines [UVSQ]
dc.contributor.authorMETZGER, Marie
hal.structure.identifierAgence de la biomédecine [Saint-Denis la Plaine]
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
dc.contributor.authorJACQUELINET, Christian
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
hal.structure.identifierCHU Bordeaux
dc.contributor.authorCOMBE, Christian
ORCID: 0000-0002-0360-573X
IDREF: 58708871
hal.structure.identifierCardiovasculaire, métabolisme, diabétologie et nutrition [CarMeN]
hal.structure.identifierCentre Hospitalier Lyon Sud [CHU - HCL] [CHLS]
dc.contributor.authorFOUQUE, Denis
hal.structure.identifierCardiovasculaire, métabolisme, diabétologie et nutrition [CarMeN]
dc.contributor.authorLAVILLE, Maurice
hal.structure.identifierCentre Hospitalier Régional Universitaire de Nancy [CHRU Nancy]
hal.structure.identifierAdaptation, mesure et évaluation en santé. Approches interdisciplinaires [APEMAC]
dc.contributor.authorFRIMAT, Luc
hal.structure.identifierUniversity of Michigan [Ann Arbor]
dc.contributor.authorROBINSON, Bruce
hal.structure.identifierArbor Research Collaborative for Health
dc.contributor.authorBIEBER, Brian
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
dc.contributor.authorSTENGEL, Bénédicte
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
dc.contributor.authorDE PINHO, Natalia Alencar
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
hal.structure.identifierHôpital Ambroise Paré [AP-HP]
dc.contributor.authorMASSY, Ziad
hal.structure.identifierMécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 [MP3CV]
hal.structure.identifierCHU Amiens-Picardie
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
hal.structure.identifierChronic Kidney Disease - Réseau Epidémiologie et Information en Néphrologie [CKD REIN]
dc.contributor.authorLIABEUF, Sophie
hal.structure.identifierCentre d'investigation clinique [Nancy] [CIC]
hal.structure.identifierCentre Hospitalier Régional Universitaire de Nancy [CHRU Nancy]
dc.contributor.authorAYAV, Carole
hal.structure.identifierAdaptation, mesure et évaluation en santé. Approches interdisciplinaires [APEMAC]
dc.contributor.authorBRIANÇON, Serge
dc.contributor.authorCANNET, Dorothée
dc.contributor.authorCOMBE, Christian
ORCID: 0000-0002-0360-573X
IDREF: 58708871
dc.contributor.authorFOUQUE, Denis
dc.contributor.authorFRIMAT, Luc
dc.contributor.authorHERPE, Yves-Edouard
dc.contributor.authorJACQUELINET, Christian
dc.contributor.authorPASCAL, Christophe
dc.contributor.authorROBINSON, Bruce
dc.contributor.authorLANGE, Céline
dc.contributor.authorLEGRAND, Karine
dc.contributor.authorMETZGER, Marie
dc.contributor.authorSPEYER, Elodie
dc.date.accessioned2024-04-19T08:57:11Z
dc.date.available2024-04-19T08:57:11Z
dc.date.issued2023-11
dc.identifier.issn0272-6386en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/199242
dc.description.abstractEnRationale & ObjectiveAdverse drug reactions (ADRs) are common in patients with chronic kidney disease (CKD). The impact of kidney function decline on serious ADR risk has been poorly investigated. We sought to comprehensively describe ADRs and assess the relationship between eGFR and serious ADR risk.Study DesignProspective cohort study.Setting & Participants3,033 participants in French Chronic Kidney Disease-Renal Epidemiology and Information Network (CKD-REIN) cohort study, a nationwide sample of nephrology outpatients with moderate-to-advanced CKD.PredictorsDemographic and biological data (including eGFR), medication prescriptions.OutcomesADRs (preventable or not) were prospectively identified from hospital discharge reports, medical records, and patient interviews. Expert pharmacologists used validated tools to adjudicate ADRs.Analytical ApproachRestricted cubic splines in fully adjusted cause-specific Cox proportional hazard models were used to evaluate the relationship between eGFR and the risk of serious ADRs (overall and by subtype).ResultsDuring a median follow-up period of 4.7 years, 360 patients experienced 488 serious ADRs. Kidney and urinary disorders (n=170) and hemorrhages (n=170) accounted for 70% of serious ADRs. The most common medications classes were antithrombotics and renin-angiotensin system inhibitors. The majority of those serious ADRs were associated with hospitalization (n=467), with 32 directly or indirectly associated with death, and 22 associated with life-threatening event. More than 27% of the 488 serious ADRs were preventable or potentially preventable. The eGFR is a major risk factor for serious ADRs. Risk of AKI was 2.2% higher and risk of bleeding ADRs were 8% higher for each 1 mL/min/1.73m2 lower baseline eGFR.LimitationsThe results cannot be extrapolated to patients who are not being followed up by a nephrologist.ConclusionsADRs constitute a major cause of hospitalization in CKD patients for whom lower eGFR level is a major risk factor.
dc.language.isoENen_US
dc.subject.enPharmacoepidemiology
dc.subject.enbleeding
dc.subject.enacute kidney injury
dc.subject.enchronic kidney disease
dc.subject.enadverse drug reaction
dc.title.enKidney Function Decline and Serious Adverse Drug Reactions in Patients With CKD
dc.typeArticle de revueen_US
dc.identifier.doi10.1053/j.ajkd.2023.09.012en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologieen_US
bordeaux.journalAmerican Journal of Kidney Diseasesen_US
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCHU de Bordeauxen_US
bordeaux.institutionInstitut Bergoniéen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-04288693
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
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