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dc.rights.licenseopenen_US
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorEHRET, Camille
hal.structure.identifierLaboratoire de Recherche Vasculaire Translationnelle [LVTS (UMR_S_1148 / U1148)]
dc.contributor.authorAID, Rachida
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorDOS SANTOS, Bruno Paiva
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorREY, Sylvie
hal.structure.identifierLaboratoire de Recherche Vasculaire Translationnelle [LVTS (UMR_S_1148 / U1148)]
dc.contributor.authorLETOURNEUR, Didier
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorAMÉDÉE VILAMITJANA, Joëlle
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorDE MONES, Erwan
dc.date.accessioned2024-04-19T08:22:30Z
dc.date.available2024-04-19T08:22:30Z
dc.date.issued2023-03-12
dc.identifier.issn1661-6596en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/199237
dc.description.abstractEnThe reconstruction of bones following tumor excision and radiotherapy remains a challenge. Our previous study, performed using polysaccharide-based microbeads that contain hydroxyapatite, found that these have osteoconductivity and osteoinductive properties. New formulations of composite microbeads containing HA particles doped with strontium (Sr) at 8 or 50% were developed to improve their biological performance and were evaluated in ectopic sites. In the current research, we characterized the materials by phase-contrast microscopy, laser dynamic scattering particle size-measurements and phosphorus content, before their implantation into two different preclinical bone defect models in rats: the femoral condyle and the segmental bone. Eight weeks after the implantation in the femoral condyle, the histology and immunohistochemistry analyses showed that Sr-doped matrices at both 8% and 50% stimulate bone formation and vascularization. A more complex preclinical model of the irradiation procedure was then developed in rats within a critical-size bone segmental defect. In the non-irradiated sites, no significant differences between the non-doped and Sr-doped microbeads were observed in the bone regeneration. Interestingly, the Sr-doped microbeads at the 8% level of substitution outperformed the vascularization process by increasing new vessel formation in the irradiated sites. These results showed that the inclusion of strontium in the matrix-stimulated vascularization in a critical-size model of bone tissue regeneration after irradiation.
dc.description.sponsorshipNouveaux produits à base de pullulane-dextrane à propriétés angiogéniques et osteogéniques pour le traitement des défauts osseux segmentaires en chirurgie orale et orthopédique. - ANR-20-CE18-0034en_US
dc.language.isoENen_US
dc.title.enBone Regeneration in Small and Large Segmental Bone Defect Models after Radiotherapy Using Injectable Polymer-Based Biodegradable Materials Containing Strontium-Doped Hydroxyapatite Particles
dc.typeArticle de revueen_US
dc.identifier.doi10.3390/ijms24065429en_US
dc.subject.halSciences du Vivant [q-bio]en_US
bordeaux.journalInternational Journal of Molecular Sciencesen_US
bordeaux.page5429en_US
bordeaux.volume24en_US
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - U1026en_US
bordeaux.issue6en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCHU de Bordeauxen_US
bordeaux.institutionInstitut Bergoniéen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcehal
hal.identifierhal-04290338
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=International%20Journal%20of%20Molecular%20Sciences&rft.date=2023-03-12&rft.volume=24&rft.issue=6&rft.spage=5429&rft.epage=5429&rft.eissn=1661-6596&rft.issn=1661-6596&rft.au=EHRET,%20Camille&AID,%20Rachida&DOS%20SANTOS,%20Bruno%20Paiva&REY,%20Sylvie&LETOURNEUR,%20Didier&rft.genre=article


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