Bone Regeneration in Small and Large Segmental Bone Defect Models after Radiotherapy Using Injectable Polymer-Based Biodegradable Materials Containing Strontium-Doped Hydroxyapatite Particles
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bioingénierie tissulaire [BIOTIS] | |
| dc.contributor.author | EHRET, Camille | |
| hal.structure.identifier | Laboratoire de Recherche Vasculaire Translationnelle [LVTS (UMR_S_1148 / U1148)] | |
| dc.contributor.author | AID, Rachida | |
| hal.structure.identifier | Bioingénierie tissulaire [BIOTIS] | |
| dc.contributor.author | DOS SANTOS, Bruno Paiva | |
| hal.structure.identifier | Bioingénierie tissulaire [BIOTIS] | |
| dc.contributor.author | REY, Sylvie | |
| hal.structure.identifier | Laboratoire de Recherche Vasculaire Translationnelle [LVTS (UMR_S_1148 / U1148)] | |
| dc.contributor.author | LETOURNEUR, Didier | |
| hal.structure.identifier | Bioingénierie tissulaire [BIOTIS] | |
| dc.contributor.author | AMÉDÉE VILAMITJANA, Joëlle | |
| hal.structure.identifier | Bioingénierie tissulaire [BIOTIS] | |
| dc.contributor.author | DE MONES, Erwan | |
| dc.date.accessioned | 2024-04-19T08:22:30Z | |
| dc.date.available | 2024-04-19T08:22:30Z | |
| dc.date.issued | 2023-03-12 | |
| dc.identifier.issn | 1661-6596 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/199237 | |
| dc.description.abstractEn | The reconstruction of bones following tumor excision and radiotherapy remains a challenge. Our previous study, performed using polysaccharide-based microbeads that contain hydroxyapatite, found that these have osteoconductivity and osteoinductive properties. New formulations of composite microbeads containing HA particles doped with strontium (Sr) at 8 or 50% were developed to improve their biological performance and were evaluated in ectopic sites. In the current research, we characterized the materials by phase-contrast microscopy, laser dynamic scattering particle size-measurements and phosphorus content, before their implantation into two different preclinical bone defect models in rats: the femoral condyle and the segmental bone. Eight weeks after the implantation in the femoral condyle, the histology and immunohistochemistry analyses showed that Sr-doped matrices at both 8% and 50% stimulate bone formation and vascularization. A more complex preclinical model of the irradiation procedure was then developed in rats within a critical-size bone segmental defect. In the non-irradiated sites, no significant differences between the non-doped and Sr-doped microbeads were observed in the bone regeneration. Interestingly, the Sr-doped microbeads at the 8% level of substitution outperformed the vascularization process by increasing new vessel formation in the irradiated sites. These results showed that the inclusion of strontium in the matrix-stimulated vascularization in a critical-size model of bone tissue regeneration after irradiation. | |
| dc.description.sponsorship | Nouveaux produits à base de pullulane-dextrane à propriétés angiogéniques et osteogéniques pour le traitement des défauts osseux segmentaires en chirurgie orale et orthopédique. - ANR-20-CE18-0034 | en_US |
| dc.language.iso | EN | en_US |
| dc.title.en | Bone Regeneration in Small and Large Segmental Bone Defect Models after Radiotherapy Using Injectable Polymer-Based Biodegradable Materials Containing Strontium-Doped Hydroxyapatite Particles | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3390/ijms24065429 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio] | en_US |
| bordeaux.journal | International Journal of Molecular Sciences | en_US |
| bordeaux.page | 5429 | en_US |
| bordeaux.volume | 24 | en_US |
| bordeaux.hal.laboratories | Bioingénierie Tissulaire (BioTis) - U1026 | en_US |
| bordeaux.issue | 6 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.institution | CHU de Bordeaux | en_US |
| bordeaux.institution | Institut Bergonié | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | hal | |
| hal.identifier | hal-04290338 | |
| hal.version | 1 | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| workflow.import.source | hal | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=International%20Journal%20of%20Molecular%20Sciences&rft.date=2023-03-12&rft.volume=24&rft.issue=6&rft.spage=5429&rft.epage=5429&rft.eissn=1661-6596&rft.issn=1661-6596&rft.au=EHRET,%20Camille&AID,%20Rachida&DOS%20SANTOS,%20Bruno%20Paiva&REY,%20Sylvie&LETOURNEUR,%20Didier&rft.genre=article |
