Overlapping Podospora anserina transcriptional responses to bacterial and fungal non self indicate a multilayered innate immune response
| hal.structure.identifier | Institut de biochimie et génétique cellulaires [IBGC] | |
| dc.contributor.author | LAMACCHIA, Marina | |
| hal.structure.identifier | Wroclaw University of Science and Technology | |
| hal.structure.identifier | Models and Algorithms for the Genome [ MAGNOME] | |
| dc.contributor.author | DYRKA, Witold | |
| hal.structure.identifier | Institut de biochimie et génétique cellulaires [IBGC] | |
| dc.contributor.author | BRETON, Annick | |
| hal.structure.identifier | Institut de biochimie et génétique cellulaires [IBGC] | |
| dc.contributor.author | SAUPE, Sven J | |
| hal.structure.identifier | Institut de biochimie et génétique cellulaires [IBGC] | |
| dc.contributor.author | PAOLETTI, Mathieu | |
| dc.date.accessioned | 2024-04-15T09:56:57Z | |
| dc.date.available | 2024-04-15T09:56:57Z | |
| dc.date.issued | 2016 | |
| dc.identifier.issn | 1664-302X | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/198878 | |
| dc.description.abstractEn | Recognition and response to non self is essential to development and survival of all organisms. It can occur between individuals of the same species or between different organisms. Fungi are established models for conspecific non self recognition in the form of vegetative incompatibility (VI), a genetically controlled process initiating a programmed cell death (PCD) leading to the rejection of a fusion cell between genetically different isolates of the same species. In Podospora anserina VI is controlled by members of the hnwd gene family encoding for proteins analogous to NOD Like Receptors (NLR) immune receptors in eukaryotes. It was hypothesized that the hnwd controlled VI reaction was derived from the fungal innate immune response. Here we analyze the P. anserina transcriptional responses to two bacterial species, Serratia fonticola to which P. anserina survives and S. marcescens to which P. anserina succumbs, and compare these to the transcriptional response induced under VI conditions. Transcriptional responses to both bacteria largely overlap, however the number of genes regulated and magnitude of regulation is more important when P. anserina survives. Transcriptional responses to bacteria also overlap with the VI reaction for both up or down regulated gene sets. Genes up regulated tend to be clustered in the genome, and display limited phylogenetic distribution. In all three responses we observed genes related to autophagy to be up-regulated. Autophagy contributes to the fungal survival in all three conditions. Genes encoding for secondary metabolites and histidine kinase signaling are also up regulated in all three conditions. Transcriptional responses also display differences. Genes involved in response to oxidative stress, or encoding small secreted proteins are essentially expressed in response to bacteria, while genes encoding NLR proteins are expressed during VI. Most functions encoded in response to bacteria favor survival of the fungus while most functions up regulated during VI would lead to cell death. These differences are discussed in the frame of a multilayered response to non self in fungi. | |
| dc.description.sponsorship | Reconnaissance hétérospécifique chez les champignons filamenteux : Des récepteurs à la réponse cellulaire - ANR-11-BSV3-0019 | |
| dc.language.iso | en | |
| dc.publisher | Frontiers Media | |
| dc.subject.en | Bacterial Fungal Interaction | |
| dc.subject.en | Vegetative incompatibility | |
| dc.subject.en | Podospora anserina | |
| dc.subject.en | Serratia marcescens | |
| dc.subject.en | Serratia fonticola | |
| dc.subject.en | Transcriptome | |
| dc.title.en | Overlapping Podospora anserina transcriptional responses to bacterial and fungal non self indicate a multilayered innate immune response | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.3389/fmicb.2016.00471 | |
| dc.subject.hal | Sciences du Vivant [q-bio]/Ecologie, Environnement/Interactions entre organismes | |
| dc.subject.hal | Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Génomique, Transcriptomique et Protéomique [q-bio.GN] | |
| dc.subject.hal | Sciences du Vivant [q-bio]/Immunologie/Immunité innée | |
| dc.subject.hal | Sciences du Vivant [q-bio]/Microbiologie et Parasitologie/Mycologie | |
| dc.subject.hal | Informatique [cs]/Bio-informatique [q-bio.QM] | |
| bordeaux.journal | Frontiers in Microbiology | |
| bordeaux.page | 471 | |
| bordeaux.volume | 7 | |
| bordeaux.hal.laboratories | Laboratoire Bordelais de Recherche en Informatique (LaBRI) - UMR 5800 | * |
| bordeaux.institution | Université de Bordeaux | |
| bordeaux.institution | Bordeaux INP | |
| bordeaux.institution | CNRS | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-01293719 | |
| hal.version | 1 | |
| hal.popular | non | |
| hal.audience | Internationale | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-01293719v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Frontiers%20in%20Microbiology&rft.date=2016&rft.volume=7&rft.spage=471&rft.epage=471&rft.eissn=1664-302X&rft.issn=1664-302X&rft.au=LAMACCHIA,%20Marina&DYRKA,%20Witold&BRETON,%20Annick&SAUPE,%20Sven%20J&PAOLETTI,%20Mathieu&rft.genre=article |
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