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Self-assembled core-shell micelles from peptide-b-polymer molecular chimeras towards structure-activity relationships

dc.rights.licenseopen
hal.structure.identifierInstitut Européen de Chimie et de Biologie [IECB]
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorDRAPPIER, Charlotte
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorDE OLIVEIRA, Hugo
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorSANDRE, Olivier
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorIBARBOURE, Emmanuel
hal.structure.identifierLaboratoire Léon Brillouin [LLB - UMR 12]
dc.contributor.authorCOMBET, Sophie
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorGARANGER, Elisabeth
IDREF: 089451740
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2013
dc.identifier.issn1359-6640
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/19861
dc.description.abstractEnThe aim of this contribution is to design, produce and characterize size-tuneable core-shell micelles from amphiphilic Tat-b-poly(trimethylene carbonate) (Tat-b-PTMC) molecular chimeras, and to explore their biological properties. Because the extensive characterization of nanomaterials is a pre-requisite to understand and rationalize their ensuing properties, we present a detailed description of Tat-b-PTMC micelles thanks to light scattering, AFM imaging and small angle neutron scattering analyses. In vitro, Tat-b-PTMC micelles were found to be rapidly and efficiently internalized by HeLa cells, with cellular uptake kinetics being mostly related to Tat peptide content and, to a lesser extent, to nanoparticle size. We also demonstrated that, after a first membrane-binding step, Tat-b-PTMC micelles were taken up by cells via an energy-dependent endocytotic process.
dc.language.isoen
dc.publisherRoyal Society of Chemistry
dc.subject.enNANOPARTICLES
dc.subject.enDESIGN
dc.subject.enDELIVERY
dc.subject.enMECHANISM
dc.subject.enBLOCK-COPOLYMERS
dc.subject.enCELLULAR UPTAKE
dc.subject.enTAT PEPTIDE
dc.subject.enHIV-1 TAT
dc.subject.enSCATTERING
dc.subject.enCYTOTOXICITY
dc.title.enSelf-assembled core-shell micelles from peptide-b-polymer molecular chimeras towards structure-activity relationships
dc.typeArticle de revue
dc.identifier.doi10.1039/c3fd00098b
dc.subject.halChimie/Polymères
bordeaux.journalFaraday Discussions
bordeaux.page83-100
bordeaux.volume166
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-00959583
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00959583v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Faraday%20Discussions&rft.date=2013&rft.volume=166&rft.spage=83-100&rft.epage=83-100&rft.eissn=1359-6640&rft.issn=1359-6640&rft.au=DRAPPIER,%20Charlotte&DE%20OLIVEIRA,%20Hugo&SANDRE,%20Olivier&IBARBOURE,%20Emmanuel&COMBET,%20Sophie&rft.genre=article


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