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Biocompatibility study of two diblock copolymeric nanoparticles for biomedical applications by in vitro toxicity testing.

dc.rights.licenseopen
hal.structure.identifierGAIKER Technological Centre
dc.contributor.authorGONI-DE-CERIO, Felipe
dc.contributor.authorMARIANI, Valentina
hal.structure.identifierAhava Dead Sea Laboratories
dc.contributor.authorCOHEN, Dror
hal.structure.identifierTev Aviv Univ, Sackler Sch Med
dc.contributor.authorMADI, Lea
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorTHEVENOT, Julie
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorOLIVEIRA, Hugo
hal.structure.identifierEuropean Commission - Joint Research Centre [Ispra] [JRC]
dc.contributor.authorUBOLDI, Chiara
hal.structure.identifierJRC Institute for Health and Consumer Protection [IHCP]
dc.contributor.authorGIUDETTI, Guido
hal.structure.identifierJRC Institute for Health and Consumer Protection [IHCP]
dc.contributor.authorCORADEGHINI, Rosella
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorGARANGER, Elisabeth
IDREF: 089451740
hal.structure.identifierJRC Institute for Health and Consumer Protection [IHCP]
dc.contributor.authorROSSI, François
hal.structure.identifierAhava Dead Sea Laboratories
dc.contributor.authorPORTUGAL-COHEN, Meital
hal.structure.identifierAhava Dead Sea Laboratories
dc.contributor.authorORON, Miriam
hal.structure.identifierTev Aviv Univ, Sackler Sch Med
dc.contributor.authorKORENSTEIN, Rafi
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorLECOMMANDOUX, Sebastien
hal.structure.identifierJRC Institute for Health and Consumer Protection [IHCP]
dc.contributor.authorPONTI, Jessica
hal.structure.identifierGAIKER Technological Centre
dc.contributor.authorSUAREZ-MERINO, Blanca
hal.structure.identifierGAIKER Technological Centre
dc.contributor.authorHEREDIA, Pedro
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2013
dc.identifier.issn1388-0764
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/19825
dc.description.abstractEnDrugs used for chemotherapy normally carry out adverse, undesired effects. Nanotechnology brings about new horizons to tackle cancer disease with a different strategy. One of the most promising approaches is the use of nanocarriers to transport active drugs. These nanocarriers need to have special properties to avoid immune responses and toxicity, and it is critical to study these effects. Nanocarriers may have different nature, but polypeptide-based copolymers have attracted considerable attention for their biocompatibility, controlled and slow biodegrad-ability as well as low toxicity. Little has been done regarding specific nanocarriers toxicity. In this study, we performed a thorough toxicological study of two different block copolymer nanoparticles (NPs); poly(trimethylene carbonate)-block-poly(L-glutamic acid) (PTMC-b-PGA) and poly(ethylene glycol)-block-poly(c-benzyl-L-glutamate) (PEG-b-PBLG) with sizes between 113 and 131 nm. Low blood-serum-protein interaction was observed. Moreover, general toxicity assays and other endpoints (apoptosis or necrosis) showed good biocompatibility for both NPs.
dc.language.isoen
dc.publisherSpringer Verlag
dc.title.enBiocompatibility study of two diblock copolymeric nanoparticles for biomedical applications by in vitro toxicity testing.
dc.typeArticle de revue
dc.identifier.doi10.1007/s11051-013-2036-0
dc.subject.halChimie
dc.subject.halChimie/Polymères
dc.subject.halSciences du Vivant [q-bio]
dc.subject.halSciences du Vivant [q-bio]/Cancer
dc.subject.halSciences du Vivant [q-bio]/Toxicologie
bordeaux.journalJournal of Nanoparticle Research
bordeaux.volume15
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-02353905
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02353905v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Nanoparticle%20Research&rft.date=2013&rft.volume=15&rft.eissn=1388-0764&rft.issn=1388-0764&rft.au=GONI-DE-CERIO,%20Felipe&MARIANI,%20Valentina&COHEN,%20Dror&MADI,%20Lea&THEVENOT,%20Julie&rft.genre=article


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