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Self-Assembly of PEG-b-PTMC Copolymers: Micelles and Polymersomes Size Control

dc.rights.licenseopen
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLEBLEU, Coralie
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorRODRIGUES, Laura
hal.structure.identifierInstitut de minéralogie, de physique des matériaux et de cosmochimie [IMPMC]
dc.contributor.authorGUIGNER, Jean-Michel
hal.structure.identifierLLB - Matière molle et biophysique [MMB]
dc.contributor.authorBRÛLET, Annie
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorGARANGER, Elisabeth
IDREF: 089451740
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2019
dc.identifier.issn0743-7463
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/19714
dc.description.abstractEnPoly(ethylene glycol)45-b-poly(trimethylene carbonate)n PEG45-b-PTMCn diblock copolymers were synthesized with five different PTMC degrees of polymerization (n = 38, 96, 144, 170, 332) and their self-assembly properties in water were studied using a manual nanoprecipitation procedure. We confirmed that the copolymer’s hydrophilic weight fraction (fPEG) is controlling nanoparticles morphology. We determined that the PEG45-b-PTMC96 with fPEG ≈ 17% is the optimal hydrophilic fraction for the stabilization of well-defined unilamellar vesicles with a membrane thickness of δ ≈ 14.6 nm. Maintaining this fraction constant and modulating the overall molar mass of the block copolymers allowed the establishment of a power law of which provides a robust correlation between the molar mass of PTMC and vesicles’ membrane thickness. Finally, we proved that controlling nanoprecipitation’s conditions by microfluidics allowed fine-tuning and control of the nanoparticles size and polydispersity index while maintaining their shape with a perfect batch-to-batch reproducibility.
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.subject.enBlock Copolymers
dc.subject.enNanoprecipitation
dc.subject.enPolymersomes
dc.subject.enMicrofluidics
dc.subject.enRing Opening Polymerization
dc.title.enSelf-Assembly of PEG-b-PTMC Copolymers: Micelles and Polymersomes Size Control
dc.typeArticle de revue
dc.identifier.doi10.1021/acs.langmuir.9b02264
dc.subject.halChimie/Polymères
dc.subject.halChimie/Matériaux
dc.subject.halPhysique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]
bordeaux.journalLangmuir
bordeaux.page13364-13374
bordeaux.volume35
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue41
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-02306925
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02306925v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Langmuir&rft.date=2019&rft.volume=35&rft.issue=41&rft.spage=13364-13374&rft.epage=13364-13374&rft.eissn=0743-7463&rft.issn=0743-7463&rft.au=LEBLEU,%20Coralie&RODRIGUES,%20Laura&GUIGNER,%20Jean-Michel&BR%C3%9BLET,%20Annie&GARANGER,%20Elisabeth&rft.genre=article


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