LEBLEU, Coralie; RODRIGUES, Laura; GUIGNER, Jean-Michel; BRÛLET, Annie; GARANGER, Elisabeth; LECOMMANDOUX, Sebastien

doi:10.1021/acs.langmuir.9b02264

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LEBLEU, Coralie
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

RODRIGUES, Laura
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

GUIGNER, Jean-Michel
Institut de minéralogie, de physique des matériaux et de cosmochimie [IMPMC]

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Langmuir. 2019, vol. 35, n° 41, p. 13364-13374

American Chemical Society

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Poly(ethylene glycol)45-b-poly(trimethylene carbonate)n PEG45-b-PTMCn diblock copolymers were synthesized with five different PTMC degrees of polymerization (n = 38, 96, 144, 170, 332) and their self-assembly properties in water were studied using a manual nanoprecipitation procedure. We confirmed that the copolymer’s hydrophilic weight fraction (fPEG) is controlling nanoparticles morphology. We determined that the PEG45-b-PTMC96 with fPEG ≈ 17% is the optimal hydrophilic fraction for the stabilization of well-defined unilamellar vesicles with a membrane thickness of δ ≈ 14.6 nm. Maintaining this fraction constant and modulating the overall molar mass of the block copolymers allowed the establishment of a power law of which provides a robust correlation between the molar mass of PTMC and vesicles’ membrane thickness. Finally, we proved that controlling nanoprecipitation’s conditions by microfluidics allowed fine-tuning and control of the nanoparticles size and polydispersity index while maintaining their shape with a perfect batch-to-batch reproducibility.< Réduire

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Block Copolymers

Nanoprecipitation

Polymersomes

Microfluidics

Ring Opening Polymerization

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Self-Assembly of PEG-b-PTMC Copolymers: Micelles and Polymersomes Size Control

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