In silico assessment of drugs effects on human embryonic stem cells derived cardiomyocytes electrical activity
hal.structure.identifier | Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN] | |
dc.contributor.author | ABBATE, Emanuela | |
hal.structure.identifier | Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN] | |
dc.contributor.author | ZEMZEMI, Nejib | |
hal.structure.identifier | Institut de Mathématiques de Bordeaux [IMB] | |
hal.structure.identifier | Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN] | |
dc.contributor.author | COUDIÈRE, Yves | |
hal.structure.identifier | Numerical simulation of biological flows [REO] | |
dc.contributor.author | GERBEAU, Jean-Frédéric | |
dc.date.accessioned | 2024-04-04T03:17:36Z | |
dc.date.available | 2024-04-04T03:17:36Z | |
dc.date.created | 2015-03-12 | |
dc.date.issued | 2015-03-12 | |
dc.date.conference | 2015-03-12 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/194320 | |
dc.description.abstractEn | Computational modeling and simulation is extensively used to investigate diseases in cardiac electrophysiological activity and also drug effects, side effects and interactions. Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) have been recently considered as a promising tool in regenerative medicine: their major role in repairing damaged tissue is due to pluripotency and ability to differentiate. These pluripotent cells are also used in early stages of drugs development. Pharmaceutical companies use the MultiElectrode Array (MEA) device in order to perform many in vitro experiments on hESC-CMs. The goal of our study is to derive a mathematical model and to simulate these in vitro experiments. | |
dc.language.iso | en | |
dc.subject.en | MEA | |
dc.subject.en | hESC-CMs | |
dc.subject.en | field potential | |
dc.subject.en | drug modelling | |
dc.title.en | In silico assessment of drugs effects on human embryonic stem cells derived cardiomyocytes electrical activity | |
dc.type | Communication dans un congrès | |
dc.subject.hal | Mathématiques [math] | |
dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire | |
dc.subject.hal | Sciences du Vivant [q-bio]/Sciences pharmaceutiques/Médicaments | |
bordeaux.hal.laboratories | Institut de Mathématiques de Bordeaux (IMB) - UMR 5251 | * |
bordeaux.institution | Université de Bordeaux | |
bordeaux.institution | Bordeaux INP | |
bordeaux.institution | CNRS | |
bordeaux.conference.title | LACM 2015 (2nd International Workshop on Latest Advances in Cardiac Modeling) | |
bordeaux.country | DE | |
bordeaux.conference.city | German Heart Center, Munich | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-01202019 | |
hal.version | 1 | |
hal.invited | non | |
hal.proceedings | non | |
hal.conference.end | 2015-03-13 | |
hal.popular | non | |
hal.audience | Internationale | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-01202019v1 | |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.date=2015-03-12&rft.au=ABBATE,%20Emanuela&ZEMZEMI,%20Nejib&COUDI%C3%88RE,%20Yves&GERBEAU,%20Jean-Fr%C3%A9d%C3%A9ric&rft.genre=unknown |
Files in this item
Files | Size | Format | View |
---|---|---|---|
There are no files associated with this item. |