Mostrar el registro sencillo del ítem

Consequences of cell-to-cell P-glycoprotein transfer on acquired multidrug resistance in breast cancer: a cell population dynamics model

hal.structure.identifierLaboratoire d'Ecotoxicologie - Milieux Aquatiques [LEMA]
dc.contributor.authorPASQUIER, Jennifer
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorMAGAL, Pierre
hal.structure.identifierLaboratoire d'Ecotoxicologie - Milieux Aquatiques [LEMA]
dc.contributor.authorBOULANGE-LECOMTE, Céline
hal.structure.identifierVanderbilt University [Nashville]
dc.contributor.authorWEBB, Glenn
hal.structure.identifierSciences Appliquées à L'Environnement [SCALE]
hal.structure.identifierLaboratoire d'Ecotoxicologie - Milieux Aquatiques [LEMA]
dc.contributor.authorLE FOLL, Frank
dc.date.accessioned2024-04-04T03:06:35Z
dc.date.available2024-04-04T03:06:35Z
dc.date.issued2011
dc.identifier.issn1745-6150
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/193347
dc.description.abstractEnBackground: Cancer is a proliferation disease affecting a genetically unstable cell population, in which molecular alterations can be somatically inherited by genetic, epigenetic or extragenetic transmission processes, leading to a cooperation of neoplastic cells within tumoural tissue. The efflux protein P-glycoprotein (P-gp) is overexpressed in many cancer cells and has known capacity to confer multidrug resistance to cytotoxic therapies. Recently, cell-to-cell P-gp transfers have been shown. Herein, we combine experimental evidence and a mathematical model to examine the consequences of an intercellular P-gp trafficking in the extragenetic transfer of multidrug resistance from resistant to sensitive cell subpopulations.
dc.language.isoen
dc.publisherBioMed Central
dc.subject.enDoxorubicin
dc.subject.enMultidrug Resistance
dc.subject.enResistant Cell
dc.subject.enSensitive Cell
dc.subject.enActivity Transfer
dc.title.enConsequences of cell-to-cell P-glycoprotein transfer on acquired multidrug resistance in breast cancer: a cell population dynamics model
dc.typeArticle de revue
dc.identifier.doi10.1186/1745-6150-6-5
dc.subject.halSciences du Vivant [q-bio]/Biologie cellulaire/Interactions cellulaires [q-bio.CB]
dc.subject.halSciences du Vivant [q-bio]/Biologie cellulaire/Organisation et fonctions cellulaires [q-bio.SC]
dc.subject.halSciences du Vivant [q-bio]/Cancer
dc.subject.halMathématiques [math]/Systèmes dynamiques [math.DS]
bordeaux.journalBiology Direct
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-01738512
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01738512v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biology%20Direct&rft.date=2011&rft.eissn=1745-6150&rft.issn=1745-6150&rft.au=PASQUIER,%20Jennifer&MAGAL,%20Pierre&BOULANGE-LECOMTE,%20C%C3%A9line&WEBB,%20Glenn&LE%20FOLL,%20Frank&rft.genre=article


Archivos en el ítem

ArchivosTamañoFormatoVer

No hay archivos asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem