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Depolarization versus repolarization abnormality underlying inferolateral J wave syndromes – new concepts in sudden cardiac death with apparently normal hearts

hal.structure.identifierIHU-LIRYC
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
hal.structure.identifierDépartement de cardiologie
dc.contributor.authorHAÏSSAGUERRE, Michel
hal.structure.identifierWhite Memorial Medical Center
dc.contributor.authorNADEMANEE, Koonlawee
hal.structure.identifierDépartement de cardiologie
hal.structure.identifierIHU-LIRYC
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorHOCINI, Mélèze
hal.structure.identifierDépartement de cardiologie
dc.contributor.authorCHENITI, Ghassen
hal.structure.identifierIHU-LIRYC
hal.structure.identifierDépartement de cardiologie
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorDUCHATEAU, Josselin
hal.structure.identifierDépartement de cardiologie
dc.contributor.authorFRONTERA, Antonio
hal.structure.identifierIHU-LIRYC
hal.structure.identifierDépartement de cardiologie
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorSACHER, Frédéric
hal.structure.identifierIHU-LIRYC
hal.structure.identifierDépartement de cardiologie
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorDERVAL, Nicolas
hal.structure.identifierIHU-LIRYC
hal.structure.identifierDépartement de cardiologie
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorDENIS, Arnaud
hal.structure.identifierIHU-LIRYC
hal.structure.identifierDépartement de cardiologie
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorPAMBRUN, Thomas
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
hal.structure.identifierIHU-LIRYC
dc.contributor.authorDUBOIS, Rémi
hal.structure.identifierIHU-LIRYC
hal.structure.identifierDépartement de cardiologie
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorJAÏS, Pierre
hal.structure.identifierIHU-LIRYC
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorBENOIST, David
hal.structure.identifierIHU-LIRYC
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorWALTON, Richard D.
hal.structure.identifierUniversité de Tsukuba = University of Tsukuba
dc.contributor.authorNOGAMI, Akihiko
hal.structure.identifierIHU-LIRYC
dc.contributor.authorCORONEL, Ruben
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
hal.structure.identifierIHU-LIRYC
dc.contributor.authorPOTSE, Mark
hal.structure.identifierIHU-LIRYC
hal.structure.identifierCentre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
dc.contributor.authorBERNUS, Olivier
dc.date.accessioned2024-04-04T03:03:38Z
dc.date.available2024-04-04T03:03:38Z
dc.date.issued2019-05
dc.identifier.issn1556-3871
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/193090
dc.description.abstractEnEarly repolarization indicates a distinct electrocardiographic phenotype affecting the junction between the QRS complex and the ST segment in inferolateral leads (inferolateral J-Wave Syndromes). It has been considered a benign electrocardiographic variant for decades, but recent clinical studies have demonstrated its arrhythmogenicity in a small subset, supported by experimental studies showing transmural dispersion of repolarization. Here, we review the current knowledge and the issues of risk stratification which limit clinical management. In addition we report on new mapping data of patients refractory to pharmacological treatment using high-density electrogram mapping at the time of inscription of J-wave. These data demonstrate that distinct substrates, delayed depolarization and abnormal early repolarization, underlie inferolateral J-wave syndromes, with significant implications. Finally, based on these data, we propose a new simplified mechanistic classification of sudden cardiac deaths without apparent structural heart disease.
dc.description.sponsorshipL'Institut de Rythmologie et modélisation Cardiaque
dc.language.isoen
dc.publisherElsevier
dc.subject.enEarly repolarization
dc.subject.enSudden death
dc.subject.enJ-wave syndromes
dc.subject.enVentricular fibrillation
dc.title.enDepolarization versus repolarization abnormality underlying inferolateral J wave syndromes – new concepts in sudden cardiac death with apparently normal hearts
dc.typeArticle de revue
dc.identifier.doi10.1016/j.hrthm.2018.10.040
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire
dc.description.sponsorshipEuropeSudden Cardiac Death and Electrical Dyssynchrony Mediated by Purkinje-His Dysfunctional Activity
bordeaux.journalHeart Rhythm
bordeaux.page781-790
bordeaux.volume16
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.issue5
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-01933810
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01933810v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Heart%20Rhythm&rft.date=2019-05&rft.volume=16&rft.issue=5&rft.spage=781-790&rft.epage=781-790&rft.eissn=1556-3871&rft.issn=1556-3871&rft.au=HA%C3%8FSSAGUERRE,%20Michel&NADEMANEE,%20Koonlawee&HOCINI,%20M%C3%A9l%C3%A8ze&CHENITI,%20Ghassen&DUCHATEAU,%20Josselin&rft.genre=article


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