HAÏSSAGUERRE, Michel; NADEMANEE, Koonlawee; HOCINI, Mélèze; CHENITI, Ghassen; DUCHATEAU, Josselin; FRONTERA, Antonio; SACHER, Frédéric; DERVAL, Nicolas; DENIS, Arnaud; PAMBRUN, Thomas; DUBOIS, Rémi; JAÏS, Pierre; BENOIST, David; WALTON, Richard D.; NOGAMI, Akihiko; CORONEL, Ruben; POTSE, Mark; BERNUS, Olivier

doi:10.1016/j.hrthm.2018.10.040

Metadatos

Licencia de uso del documento

HAÏSSAGUERRE, Michel
IHU-LIRYC
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
Département de cardiologie

NADEMANEE, Koonlawee
White Memorial Medical Center

HOCINI, Mélèze
Département de cardiologie
IHU-LIRYC
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]

Idioma

Article de revue

Este ítem está publicado en

Heart Rhythm. 2019-05, vol. 16, n° 5, p. 781-790

Elsevier

Resumen en inglés

Early repolarization indicates a distinct electrocardiographic phenotype affecting the junction between the QRS complex and the ST segment in inferolateral leads (inferolateral J-Wave Syndromes). It has been considered a benign electrocardiographic variant for decades, but recent clinical studies have demonstrated its arrhythmogenicity in a small subset, supported by experimental studies showing transmural dispersion of repolarization. Here, we review the current knowledge and the issues of risk stratification which limit clinical management. In addition we report on new mapping data of patients refractory to pharmacological treatment using high-density electrogram mapping at the time of inscription of J-wave. These data demonstrate that distinct substrates, delayed depolarization and abnormal early repolarization, underlie inferolateral J-wave syndromes, with significant implications. Finally, based on these data, we propose a new simplified mechanistic classification of sudden cardiac deaths without apparent structural heart disease.< Leer menos

Palabras clave en inglés

Early repolarization

Sudden death

J-wave syndromes

Ventricular fibrillation

URI

https://oskar-bordeaux.fr/handle/20.500.12278/193090

DOI

http://dx.doi.org/10.1016/j.hrthm.2018.10.040

Proyecto europeo

Sudden Cardiac Death and Electrical Dyssynchrony Mediated by Purkinje-His Dysfunctional Activity

Proyecto ANR

L'Institut de Rythmologie et modélisation Cardiaque

Orígen

Importado de Hal

Centros de investigación

Institut de Mathématiques de Bordeaux (IMB) - UMR 5251