Depolarization versus repolarization abnormality underlying inferolateral J wave syndromes – new concepts in sudden cardiac death with apparently normal hearts
HAÏSSAGUERRE, Michel
IHU-LIRYC
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
Département de cardiologie
IHU-LIRYC
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
Département de cardiologie
HOCINI, Mélèze
Département de cardiologie
IHU-LIRYC
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
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Département de cardiologie
IHU-LIRYC
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
HAÏSSAGUERRE, Michel
IHU-LIRYC
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
Département de cardiologie
IHU-LIRYC
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
Département de cardiologie
HOCINI, Mélèze
Département de cardiologie
IHU-LIRYC
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
Département de cardiologie
IHU-LIRYC
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
DUCHATEAU, Josselin
IHU-LIRYC
Département de cardiologie
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
IHU-LIRYC
Département de cardiologie
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
SACHER, Frédéric
IHU-LIRYC
Département de cardiologie
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
IHU-LIRYC
Département de cardiologie
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
DERVAL, Nicolas
IHU-LIRYC
Département de cardiologie
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
IHU-LIRYC
Département de cardiologie
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
DENIS, Arnaud
IHU-LIRYC
Département de cardiologie
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
IHU-LIRYC
Département de cardiologie
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
PAMBRUN, Thomas
IHU-LIRYC
Département de cardiologie
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
IHU-LIRYC
Département de cardiologie
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
JAÏS, Pierre
IHU-LIRYC
Département de cardiologie
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
IHU-LIRYC
Département de cardiologie
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
POTSE, Mark
Institut de Mathématiques de Bordeaux [IMB]
Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
IHU-LIRYC
< Reduce
Institut de Mathématiques de Bordeaux [IMB]
Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
IHU-LIRYC
Language
en
Article de revue
This item was published in
Heart Rhythm. 2019-05, vol. 16, n° 5, p. 781-790
Elsevier
English Abstract
Early repolarization indicates a distinct electrocardiographic phenotype affecting the junction between the QRS complex and the ST segment in inferolateral leads (inferolateral J-Wave Syndromes). It has been considered a ...Read more >
Early repolarization indicates a distinct electrocardiographic phenotype affecting the junction between the QRS complex and the ST segment in inferolateral leads (inferolateral J-Wave Syndromes). It has been considered a benign electrocardiographic variant for decades, but recent clinical studies have demonstrated its arrhythmogenicity in a small subset, supported by experimental studies showing transmural dispersion of repolarization. Here, we review the current knowledge and the issues of risk stratification which limit clinical management. In addition we report on new mapping data of patients refractory to pharmacological treatment using high-density electrogram mapping at the time of inscription of J-wave. These data demonstrate that distinct substrates, delayed depolarization and abnormal early repolarization, underlie inferolateral J-wave syndromes, with significant implications. Finally, based on these data, we propose a new simplified mechanistic classification of sudden cardiac deaths without apparent structural heart disease.Read less <
English Keywords
Early repolarization
Sudden death
J-wave syndromes
Ventricular fibrillation
European Project
Sudden Cardiac Death and Electrical Dyssynchrony Mediated by Purkinje-His Dysfunctional Activity
ANR Project
L'Institut de Rythmologie et modélisation Cardiaque
Origin
Hal imported