Quantitative mathematical modeling of clinical brain metastasis dynamics in non-small cell lung cancer
hal.structure.identifier | Modélisation Mathématique pour l'Oncologie [MONC] | |
dc.contributor.author | BILOUS, Maria | |
hal.structure.identifier | Simulation and Modeling of Adaptive Response for Therapeutics in Cancer [SMARTc] | |
dc.contributor.author | SERDJEBI, Cindy | |
hal.structure.identifier | Simulation and Modeling of Adaptive Response for Therapeutics in Cancer [SMARTc] | |
hal.structure.identifier | Service d'oncologie multidisciplinaire innovations thérapeutiques [Hôpital Nord - APHM] | |
dc.contributor.author | BOYER, Arnaud | |
hal.structure.identifier | Hôpital Haut-Lévêque [CHU Bordeaux] | |
dc.contributor.author | POUYPOUDAT, Claudia | |
hal.structure.identifier | Service d'oncologie multidisciplinaire innovations thérapeutiques [Hôpital Nord - APHM] | |
dc.contributor.author | TOMASINI, Pascale | |
hal.structure.identifier | Simulation and Modeling of Adaptive Response for Therapeutics in Cancer [SMARTc] | |
dc.contributor.author | BARBOLOSI, Dominique | |
hal.structure.identifier | Simulation and Modeling of Adaptive Response for Therapeutics in Cancer [SMARTc] | |
hal.structure.identifier | Service d'oncologie multidisciplinaire innovations thérapeutiques [Hôpital Nord - APHM] | |
hal.structure.identifier | Centre de Recherche en Cancérologie de Marseille [CRCM] | |
dc.contributor.author | BARLESI, Fabrice | |
hal.structure.identifier | Institut Bergonié [Bordeaux] | |
dc.contributor.author | CHOMY, François | |
hal.structure.identifier | Modélisation Mathématique pour l'Oncologie [MONC] | |
hal.structure.identifier | Institut de Mathématiques de Bordeaux [IMB] | |
dc.contributor.author | BENZEKRY, Sébastien | |
dc.date.accessioned | 2024-04-04T02:59:55Z | |
dc.date.available | 2024-04-04T02:59:55Z | |
dc.date.issued | 2019-09 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/192781 | |
dc.description.abstractEn | Brain metastases (BMs) are the largest disabling site for non-small cell lung cancers, but are only visible when sizeable. Individualized prediction of the BM risk and extent is a major challenge for therapeutic decision. This study assesses mechanistic models of BM apparition and growth against clinical imaging data.We implemented a quantitative computational method to confront biologicallyinformed mathematical models to clinical data of BMs. Primary tumor growth parameters were estimated from size at diagnosis and histology. Metastatic dissemination and growth parameters were fitted to either population data of BM probability (n=183 patients) or longitudinal measurements of number and size of visible BMs (63 size measurements in two patients). Pre-clinical phases from first cancer cell to detection were estimated to 2.1-5.3 years. A model featuringdormancy was best able to describe the longitudinal data, as well as BM probability as a function of primary tumor size at diagnosis. It predicted first appearance of BMs at 14-19 months pre-diagnosis. Model-informed predictions of invisible cerebral disease burden could be used to inform therapeutic intervention. | |
dc.language.iso | en | |
dc.publisher | Nature Publishing Group | |
dc.title.en | Quantitative mathematical modeling of clinical brain metastasis dynamics in non-small cell lung cancer | |
dc.type | Article de revue | |
dc.identifier.doi | 10.1038/s41598-019-49407-3 | |
dc.subject.hal | Sciences du Vivant [q-bio]/Cancer | |
dc.subject.hal | Informatique [cs]/Modélisation et simulation | |
dc.subject.hal | Mathématiques [math] | |
bordeaux.journal | Scientific Reports | |
bordeaux.volume | 9 | |
bordeaux.hal.laboratories | Institut de Mathématiques de Bordeaux (IMB) - UMR 5251 | * |
bordeaux.issue | 1 | |
bordeaux.institution | Université de Bordeaux | |
bordeaux.institution | Bordeaux INP | |
bordeaux.institution | CNRS | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-01928442 | |
hal.version | 1 | |
hal.popular | non | |
hal.audience | Internationale | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-01928442v1 | |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scientific%20Reports&rft.date=2019-09&rft.volume=9&rft.issue=1&rft.eissn=2045-2322&rft.issn=2045-2322&rft.au=BILOUS,%20Maria&SERDJEBI,%20Cindy&BOYER,%20Arnaud&POUYPOUDAT,%20Claudia&TOMASINI,%20Pascale&rft.genre=article |
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