Role of L-type Calcium in Modulating Pro-Arrhythmic Effects of Dofetilide in Human
| hal.structure.identifier | Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN] | |
| dc.contributor.author | ZEMZEMI, Nejib | |
| hal.structure.identifier | Universitat Politècnica de València = Universitad Politecnica de Valencia = Polytechnic University of Valencia [UPV] | |
| dc.contributor.author | SAIZ RODRIGUEZ, Javier | |
| hal.structure.identifier | Computing Science Laboratory - Oxford University | |
| dc.contributor.author | BLANCA, Rodriguez | |
| dc.date.accessioned | 2024-04-04T02:23:40Z | |
| dc.date.available | 2024-04-04T02:23:40Z | |
| dc.date.issued | 2012-10-17 | |
| dc.date.conference | 2012-09-09 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/189753 | |
| dc.description.abstractEn | Dofetilide is a class III drug whose use needs to be monitored due to the possible occurrence of Torsades de Pointes (TdP). The mechanisms are unclear but research suggests that both early-afterdepolarizations (EAD) and increased dispersion of action potential duration (APD) might be involved. Importantly, drug-induced TdP is more common in women, possibly due to higher L-type calcium current (ICaL) levels. Our goal is to use numerical simula- tion in order to investigate pro-arrhythmic mechanisms of dofetilide in human by characterizing its effects on APD, APD dispersion and EAD formation for varying doses and ICaL levels. | |
| dc.language.iso | en | |
| dc.publisher | IEEE | |
| dc.source.title | Computing in Cardiology (CinC), 2012 | |
| dc.title.en | Role of L-type Calcium in Modulating Pro-Arrhythmic Effects of Dofetilide in Human | |
| dc.type | Communication dans un congrès | |
| dc.subject.hal | Mathématiques [math]/Equations aux dérivées partielles [math.AP] | |
| dc.subject.hal | Mathématiques [math]/Analyse numérique [math.NA] | |
| dc.description.sponsorshipEurope | Computational Prediction of Drug Cardiac Toxicity | |
| bordeaux.page | 861-864 | |
| bordeaux.hal.laboratories | Institut de Mathématiques de Bordeaux (IMB) - UMR 5251 | * |
| bordeaux.institution | Université de Bordeaux | |
| bordeaux.institution | Bordeaux INP | |
| bordeaux.institution | CNRS | |
| bordeaux.conference.title | CinC 2012 - Computing in Cardiology | |
| bordeaux.country | PL | |
| bordeaux.title.proceeding | Computing in Cardiology (CinC), 2012 | |
| bordeaux.conference.city | Krakow | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-00764090 | |
| hal.version | 1 | |
| hal.invited | non | |
| hal.proceedings | oui | |
| hal.conference.end | 2012-09-12 | |
| hal.popular | non | |
| hal.audience | Internationale | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-00764090v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.btitle=Computing%20in%20Cardiology%20(CinC),%202012&rft.date=2012-10-17&rft.spage=861-864&rft.epage=861-864&rft.au=ZEMZEMI,%20Nejib&SAIZ%20RODRIGUEZ,%20Javier&BLANCA,%20Rodriguez&rft.genre=unknown |
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