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dc.rights.licenseopenen_US
hal.structure.identifierCentro de Estudios Científicos [CECs]
dc.contributor.authorBARROS, Luis Felipe
hal.structure.identifierCentro de Estudios Científicos [CECs]
dc.contributor.authorRUMINOT, Ivan
hal.structure.identifierMax Planck Institute for Metabolism Research [Cologne, Allemagne]
dc.contributor.authorSOTELO-HITSCHFELD, Tamara
hal.structure.identifierCommissariat à l'énergie atomique et aux énergies alternatives [CEA]
dc.contributor.authorLERCHUNDI, Rodrigo
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorFERNANDEZ-MONCADA, Ignacio
dc.date.accessioned2024-02-15T16:51:49Z
dc.date.available2024-02-15T16:51:49Z
dc.date.issued2023-02-10
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/188172
dc.description.abstractEnInformation processing imposes urgent metabolic demands on neurons, which have negligible energy stores and restricted access to fuel. Here, we discuss metabolic recruitment, the tissue-level phenomenon whereby active neurons harvest resources from their surroundings. The primary event is the neuronal release of K+ that mirrors workload. Astrocytes sense K+ in exquisite fashion thanks to their unique coexpression of NBCe1 and α2β2 Na+/K+ ATPase, and within seconds switch to Crabtree metabolism, involving GLUT1, aerobic glycolysis, transient suppression of mitochondrial respiration, and lactate export. The lactate surge serves as a secondary recruiter by inhibiting glucose consumption in distant cells. Additional recruiters are glutamate, nitric oxide, and ammonium, which signal over different spatiotemporal domains. The net outcome of these events is that more glucose, lactate, and oxygen are made available. Metabolic recruitment works alongside neurovascular coupling and various averaging strategies to support the inordinate dynamic range of individual neurons. Copyright © 2023 by the author(s).
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enNeurons
dc.subject.enAstrocytes
dc.subject.enGlucose
dc.subject.enLactate
dc.subject.enOxygen
dc.subject.enGlycolysis
dc.subject.enMitochondria
dc.title.enMetabolic Recruitment in Brain Tissue
dc.title.alternativeAnnu Rev Physiolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1146/annurev-physiol-021422-091035en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed36270291en_US
bordeaux.journalAnnual Review of Physiologyen_US
bordeaux.page115-135en_US
bordeaux.volume85en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamEndocannabinoïdes et Neuroadaptationen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04460485
hal.version1
hal.date.transferred2024-02-15T16:51:52Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Annual%20Review%20of%20Physiology&rft.date=2023-02-10&rft.volume=85&rft.spage=115-135&rft.epage=115-135&rft.au=BARROS,%20Luis%20Felipe&RUMINOT,%20Ivan&SOTELO-HITSCHFELD,%20Tamara&LERCHUNDI,%20Rodrigo&FERNANDEZ-MONCADA,%20Ignacio&rft.genre=article


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