BARROS, Luis Felipe; RUMINOT, Ivan; SOTELO-HITSCHFELD, Tamara; LERCHUNDI, Rodrigo; FERNANDEZ-MONCADA, Ignacio

doi:10.1146/annurev-physiol-021422-091035

BARROS, Luis Felipe
Centro de Estudios Científicos [CECs]

RUMINOT, Ivan
Centro de Estudios Científicos [CECs]

SOTELO-HITSCHFELD, Tamara
Max Planck Institute for Metabolism Research [Cologne, Allemagne]

Idioma

Article de revue

Este ítem está publicado en

Annual Review of Physiology. 2023-02-10, vol. 85, p. 115-135

Resumen en inglés

Information processing imposes urgent metabolic demands on neurons, which have negligible energy stores and restricted access to fuel. Here, we discuss metabolic recruitment, the tissue-level phenomenon whereby active neurons harvest resources from their surroundings. The primary event is the neuronal release of K+ that mirrors workload. Astrocytes sense K+ in exquisite fashion thanks to their unique coexpression of NBCe1 and α2β2 Na+/K+ ATPase, and within seconds switch to Crabtree metabolism, involving GLUT1, aerobic glycolysis, transient suppression of mitochondrial respiration, and lactate export. The lactate surge serves as a secondary recruiter by inhibiting glucose consumption in distant cells. Additional recruiters are glutamate, nitric oxide, and ammonium, which signal over different spatiotemporal domains. The net outcome of these events is that more glucose, lactate, and oxygen are made available. Metabolic recruitment works alongside neurovascular coupling and various averaging strategies to support the inordinate dynamic range of individual neurons. Copyright © 2023 by the author(s).< Leer menos

Palabras clave en inglés

Neurons

Astrocytes

Glucose

Lactate

Oxygen

Glycolysis

Mitochondria

URI

https://oskar-bordeaux.fr/handle/20.500.12278/188172

DOI

http://dx.doi.org/10.1146/annurev-physiol-021422-091035

Centros de investigación

Neurocentre Magendie - U1215

Ver/Abrir

Metadatos

Compartir este ítem

Licencia de uso del documento

Metabolic Recruitment in Brain Tissue

Idioma

Este ítem está publicado en

Resumen en inglés

Palabras clave en inglés

URI

DOI

Centros de investigación