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dc.rights.licenseauthentificationen_US
dc.contributor.advisorFROELIGER, Alizée
dc.contributor.authorTURLIER, Julie
dc.date2023-10-13
dc.date.accessioned2024-02-12T16:38:21Z
dc.date.available2024-02-12T16:38:21Z
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/188056
dc.description.abstractObjectif : évaluer les issues de grossesse dans une cohorte de femmes SOPK, et quantifier le risque de ces issues de grossesse selon l’indice de masse corporelle (IMC) pré-conceptionnel. Matériel et méthodes : étude rétrospective incluant les grossesses issues de femmes SOPK au CHU de Bordeaux, de janvier 2016 à novembre 2022. Résultats : L’échantillon final comprenait 340 femmes SOPK : 176 (51,8 %) avaient un poids normal, 72 (21,2 %) étaient en surpoids et 92 (27 %) étaient obèses. Le taux de diabète gestationnel (DG) était de 29,1%, d’HTA gravidique de 1,5%, de pré-éclampsie de 4,4%, de PAG de 4.4%, de RCIU de 5.6%, de césarienne de 17.1%, de macrosomie de 8.8% et de prématurité de 4.7%. Le taux de DG était significativement plus élevé dans les groupes de femmes obèses (48,8%) et en surpoids (33,3%) (p<0,01) et le taux d’HTA gravidique significativement plus élevé dans le groupe de femmes en surpoids (4,4%) et obèses (2,4%) (p=0,03). Il y avait significativement plus de césarienne pour causes maternelles dans le groupe de femmes obèses et en surpoids par rapport au groupe de femmes de poids normal (p = 0,04). Nous n’avons pas trouvé de différence significative entre les groupes sur les autres complications de grossesse étudiées. Après ajustement sur les facteurs de confusion disponibles, toutes les complications de grossesse semblaient être progressivement augmentées avec l’augmentation de l’IMC mais la différence n’était significative que pour le DG. Conclusion : dans notre population de femmes atteintes du SOPK, le taux de DG et de pré-éclampsie semblaient plus élevés que dans une population générale de femmes enceintes. Avoir un IMC préconceptionnel élevé semble être un facteur de risque supplémentaire de DG et d’HTA gravidique chez les femmes SOPK. Il pourrait être utile d’informer les femmes atteintes du SOPK du risque accru de complications pendant la grossesse, et d’encourager la perte de poids chez les femmes ayant un IMC élevé, afin de limiter ce risque.
dc.description.abstractEnObjective: to assess pregnancy outcomes in a cohort of polycystic ovary syndrome (PCOS) women, and to quantify the risk of these pregnancy outcomes according to the pre-pregnancy body mass index (BMI). Study design: retrospective and monocentric study including all PCOS women in a French tertiary-care university hospital in Bordeaux, from January 2016 through November 2022. Data about characteristics of women, pregnancy, delivery, and newborns were collected from medical charts. Our cohort was stratified according to the pre-pregnancy BMI into three groups: normal weight, overweight and obesity. Were assessed pregnancy outcomes, including gestational diabetes mellitus (GDM), pregnancy induced hypertension (PIH), preeclampsia, and others outcomes such as preterm birth, fetuses small for age gestational (SGA), fetal growth restriction (FGR), macrosomia, cesarean delivery and operative vaginal delivery. Association between pre-pregnancy BMI and each complication of pregnancy were analyzed by univariate and multivariate logistic regression with adjustment on available confounders. Results: among 39,178 births during the study period, 406 (1.0%) women were identified PCOS, and after exclusion of 66 women, the final sample comprised 340 PCOS women : 176 (51,8%) had normal weight, 72 (21,2%) were overweight and 92 (27%) were obeses. In our population, the rate of GDM was 29.1%, PIH 1.5%, preeclampsia 4.4%, SGA 1.5%, FGR 5.6%, cesarean delivery 17.1%, operative vaginal delivery 15.6%, macrosomia 8.8%, and preterm birth (before 34 weeks) 4.7%. Stratifying by the BMI, a significantly higher risk of pregnancy complications was found for metabolic pathologies such as GDM or PIH. The rate of GDM was significantly higher in obese (48.8%) and overweight women groups (33.3%) compared to the normal weight group (p <0.01), as the rate of PIH wich was significantly higher in overweight women group (4.4%) and obese women (2.4%) (p=0.03). We did not find any significant difference on the overall rate of cesarean delivery (p=0.08) but there was significantly more cesarean delivery for maternal cause in obese and overweight women group compared to normal weight women group (p=0.04). We did not find any significant difference between groups about other studied complications of pregnancy (preeclampsia, SGA, FGR, macrosomia, preterm birth, and operative vaginal delivery). After adjustment for available counfonders, all pregnancy complications seemed to be gradually increased in case of obesity more than in overweight but the difference is significant only for GDM (aOR 3.5, 95% CI 1.6-5.7 and aOR 6.7, 95% CI 3.8-10.5 respectively for overweight and obese women groups). Conclusion: in our population of PCOS women, the rate of GDM and preeclampsia appeared to be higher than in a general population of pregnant women. Having a higher pre-pregnancy BMI is an additional risk factor of GDM and PIH among PCOS women, and it appears to be a tendency for increasing the risk of other outcomes studied. It could be useful to inform women with PCOS of the increased risk of complications during pregnancy, and to encourage weight loss in women with a high BMI, in order to limit this risk.
dc.language.isoFRen_US
dc.subjectSyndrome des ovaires polykystiques (SOPK)
dc.subjectIndice de masse corporelle (IMC)
dc.subjectSurpoids
dc.subjectObésité
dc.subjectGrossesse
dc.subjectDiabète gestationnel (DG)
dc.subjectHypertension gravidique (HTA gravidique)
dc.subjectPrééclampsie
dc.subject.enPolycystic ovary syndrome (PCOS)
dc.subject.enBody mass index (BMI)
dc.subject.enOverweight
dc.subject.enObesity
dc.subject.enPregnancy
dc.subject.enGestational diabetes mellitus (GDM)
dc.subject.enPregnancy induced hypertension (PIH)
dc.subject.enPreeclampsia
dc.titleComplications obstétricales chez des femmes atteintes d'un syndrome des ovaires polykystiques et effet de l'indice de masse corporelle pré conceptionnel : une étude de cohorte rétrospective
dc.title.enPregnancy outcomes among women with polycystic ovary syndrome and effect of the pre pregnancy body mass index: a retrospective cohort study
dc.typeThèse d'exerciceen_US
dc.subject.halSciences du Vivant [q-bio]en_US
bordeaux.hal.laboratoriesThèses d’exercice de l’Université de Bordeauxen_US
bordeaux.type.institutionUniversité de Bordeauxen_US
bordeaux.thesis.typethèse d'exercice de médecine spécialiséeen_US
bordeaux.thesis.disciplineGynécologie médicaleen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.title=Complications%20obst%C3%A9tricales%20chez%20des%20femmes%20atteintes%20d'un%20syndrome%20des%20ovaires%20polykystiques%20et%20effet%20de%20l'indice%20de%20masse%20corpore&amp;rft.atitle=Complications%20obst%C3%A9tricales%20chez%20des%20femmes%20atteintes%20d'un%20syndrome%20des%20ovaires%20polykystiques%20et%20effet%20de%20l'indice%20de%20masse%20corpor&amp;rft.au=TURLIER,%20Julie&amp;rft.genre=unknown


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