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Cassette recombination dynamics within chromosomal integrons are regulated by toxin-antitoxin systems.

dc.rights.licenseopenen_US
hal.structure.identifierInstitut Pasteur [Paris] [IP]
dc.contributor.authorRICHARD, Egill
hal.structure.identifierInstitut Pasteur [Paris] [IP]
dc.contributor.authorDARRACQ, Baptiste
hal.structure.identifierInstitut Pasteur [Paris] [IP]
dc.contributor.authorLITTNER, Eloi
hal.structure.identifierInstitut Pasteur [Paris] [IP]
dc.contributor.authorVIT, Claire
hal.structure.identifierInstitut Pasteur [Paris] [IP]
dc.contributor.authorWHITEWAY, Clémence
hal.structure.identifierInstitut Pasteur [Paris] [IP]
dc.contributor.authorBOS, Julia
hal.structure.identifierInstitut Pasteur [Paris] [IP]
dc.contributor.authorFOURNES, Florian
hal.structure.identifierInstitut Pasteur [Paris] [IP]
dc.contributor.authorGARRISS, Geneviève
hal.structure.identifierInstitut Pasteur [Paris] [IP]
dc.contributor.authorCONTE, Valentin
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorLAPAILLERIE, Delphine
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorPARISSI, Vincent
hal.structure.identifierInstitut Pasteur [Paris] [IP]
dc.contributor.authorROUSSET, François
hal.structure.identifierRoskilde University
dc.contributor.authorSKOVGAARD, Ole
dc.contributor.authorBIKARD, David
hal.structure.identifierInstitut Pasteur [Paris] [IP]
hal.structure.identifierGénétique des génomes - Genetics of Genomes [UMR 3525]
dc.contributor.authorROCHA, Eduardo P C
hal.structure.identifierInstitut Pasteur [Paris] [IP]
dc.contributor.authorMAZEL, Didier
hal.structure.identifierInstitut Pasteur [Paris] [IP]
dc.contributor.authorLOOT, Céline
dc.date.accessioned2024-01-16T14:07:32Z
dc.date.available2024-01-16T14:07:32Z
dc.date.issued2024-01-12
dc.identifier.issn2375-2548en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/187273
dc.description.abstractEnIntegrons are adaptive bacterial devices that rearrange promoter-less gene cassettes into variable ordered arrays under stress conditions, thereby sampling combinatorial phenotypic diversity. Chromosomal integrons often carry hundreds of silent gene cassettes, with integrase-mediated recombination leading to rampant DNA excision and integration, posing a potential threat to genome integrity. How this activity is regulated and controlled, particularly through selective pressures, to maintain such large cassette arrays is unknown. Here, we show a key role of promoter-containing toxin-antitoxin (TA) cassettes as systems that kill the cell when the overall cassette excision rate is too high. These results highlight the importance of TA cassettes regulating the cassette recombination dynamics and provide insight into the evolution and success of integrons in bacterial genomes.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.subject.enIntegrons
dc.subject.enToxin-Antitoxin Systems
dc.subject.enBacteria
dc.subject.enGenome
dc.subject.enBacterial
dc.subject.enRecombination
dc.subject.enGenetic
dc.title.enCassette recombination dynamics within chromosomal integrons are regulated by toxin-antitoxin systems.
dc.title.alternativeSci Adven_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1126/sciadv.adj3498en_US
dc.subject.halSciences du Vivant [q-bio]/Microbiologie et Parasitologieen_US
dc.identifier.pubmed38215203en_US
bordeaux.journalScience Advancesen_US
bordeaux.pageeadj3498en_US
bordeaux.volume10en_US
bordeaux.hal.laboratoriesMFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234en_US
bordeaux.issue2en_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04397951
hal.version1
hal.date.transferred2024-01-16T14:07:36Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Science%20Advances&rft.date=2024-01-12&rft.volume=10&rft.issue=2&rft.spage=eadj3498&rft.epage=eadj3498&rft.eissn=2375-2548&rft.issn=2375-2548&rft.au=RICHARD,%20Egill&DARRACQ,%20Baptiste&LITTNER,%20Eloi&VIT,%20Claire&WHITEWAY,%20Cl%C3%A9mence&rft.genre=article


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