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Cassette recombination dynamics within chromosomal integrons are regulated by toxin-antitoxin systems.
dc.rights.license | open | en_US |
hal.structure.identifier | Institut Pasteur [Paris] [IP] | |
dc.contributor.author | RICHARD, Egill | |
hal.structure.identifier | Institut Pasteur [Paris] [IP] | |
dc.contributor.author | DARRACQ, Baptiste | |
hal.structure.identifier | Institut Pasteur [Paris] [IP] | |
dc.contributor.author | LITTNER, Eloi | |
hal.structure.identifier | Institut Pasteur [Paris] [IP] | |
dc.contributor.author | VIT, Claire | |
hal.structure.identifier | Institut Pasteur [Paris] [IP] | |
dc.contributor.author | WHITEWAY, Clémence | |
hal.structure.identifier | Institut Pasteur [Paris] [IP] | |
dc.contributor.author | BOS, Julia | |
hal.structure.identifier | Institut Pasteur [Paris] [IP] | |
dc.contributor.author | FOURNES, Florian | |
hal.structure.identifier | Institut Pasteur [Paris] [IP] | |
dc.contributor.author | GARRISS, Geneviève | |
hal.structure.identifier | Institut Pasteur [Paris] [IP] | |
dc.contributor.author | CONTE, Valentin | |
hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
dc.contributor.author | LAPAILLERIE, Delphine | |
hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
dc.contributor.author | PARISSI, Vincent | |
hal.structure.identifier | Institut Pasteur [Paris] [IP] | |
dc.contributor.author | ROUSSET, François | |
hal.structure.identifier | Roskilde University | |
dc.contributor.author | SKOVGAARD, Ole | |
dc.contributor.author | BIKARD, David | |
hal.structure.identifier | Institut Pasteur [Paris] [IP] | |
hal.structure.identifier | Génétique des génomes - Genetics of Genomes [UMR 3525] | |
dc.contributor.author | ROCHA, Eduardo P C | |
hal.structure.identifier | Institut Pasteur [Paris] [IP] | |
dc.contributor.author | MAZEL, Didier | |
hal.structure.identifier | Institut Pasteur [Paris] [IP] | |
dc.contributor.author | LOOT, Céline | |
dc.date.accessioned | 2024-01-16T14:07:32Z | |
dc.date.available | 2024-01-16T14:07:32Z | |
dc.date.issued | 2024-01-12 | |
dc.identifier.issn | 2375-2548 | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/187273 | |
dc.description.abstractEn | Integrons are adaptive bacterial devices that rearrange promoter-less gene cassettes into variable ordered arrays under stress conditions, thereby sampling combinatorial phenotypic diversity. Chromosomal integrons often carry hundreds of silent gene cassettes, with integrase-mediated recombination leading to rampant DNA excision and integration, posing a potential threat to genome integrity. How this activity is regulated and controlled, particularly through selective pressures, to maintain such large cassette arrays is unknown. Here, we show a key role of promoter-containing toxin-antitoxin (TA) cassettes as systems that kill the cell when the overall cassette excision rate is too high. These results highlight the importance of TA cassettes regulating the cassette recombination dynamics and provide insight into the evolution and success of integrons in bacterial genomes. | |
dc.language.iso | EN | en_US |
dc.rights | Attribution-NonCommercial 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/us/ | * |
dc.subject.en | Integrons | |
dc.subject.en | Toxin-Antitoxin Systems | |
dc.subject.en | Bacteria | |
dc.subject.en | Genome | |
dc.subject.en | Bacterial | |
dc.subject.en | Recombination | |
dc.subject.en | Genetic | |
dc.title.en | Cassette recombination dynamics within chromosomal integrons are regulated by toxin-antitoxin systems. | |
dc.title.alternative | Sci Adv | en_US |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1126/sciadv.adj3498 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Microbiologie et Parasitologie | en_US |
dc.identifier.pubmed | 38215203 | en_US |
bordeaux.journal | Science Advances | en_US |
bordeaux.page | eadj3498 | en_US |
bordeaux.volume | 10 | en_US |
bordeaux.hal.laboratories | MFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234 | en_US |
bordeaux.issue | 2 | en_US |
bordeaux.institution | CNRS | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
bordeaux.import.source | pubmed | |
hal.identifier | hal-04397951 | |
hal.version | 1 | |
hal.date.transferred | 2024-01-16T14:07:36Z | |
hal.popular | non | en_US |
hal.audience | Internationale | en_US |
hal.export | true | |
workflow.import.source | pubmed | |
dc.rights.cc | Pas de Licence CC | en_US |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Science%20Advances&rft.date=2024-01-12&rft.volume=10&rft.issue=2&rft.spage=eadj3498&rft.epage=eadj3498&rft.eissn=2375-2548&rft.issn=2375-2548&rft.au=RICHARD,%20Egill&DARRACQ,%20Baptiste&LITTNER,%20Eloi&VIT,%20Claire&WHITEWAY,%20Cl%C3%A9mence&rft.genre=article |