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Subjects suffering from bipolar disorder taking lithium are less likely to report physical pain: a FACE-BD study

dc.rights.licenseopenen_US
hal.structure.identifierInstitut de Génomique Fonctionnelle [IGF]
hal.structure.identifierCentre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
dc.contributor.authorRISCH, Nathan
hal.structure.identifierInstitut de Génomique Fonctionnelle [IGF]
hal.structure.identifierCentre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
dc.contributor.authorDUBOIS, Jonathan
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierHôpital Lariboisière-Fernand-Widal [APHP]
hal.structure.identifierOptimisation thérapeutique en Neuropsychopharmacologie [OPTeN (UMR_S 1144 / U1144)]
dc.contributor.authorETAIN, Bruno
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierCentre hospitalier Charles Perrens [Bordeaux]
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAOUIZERATE, Bruno
hal.structure.identifierHôpital Lariboisière-Fernand-Widal [APHP]
hal.structure.identifierOptimisation thérapeutique en Neuropsychopharmacologie [OPTeN (UMR_S 1144 / U1144)]
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorBELLIVIER, Frank
hal.structure.identifierCentre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
hal.structure.identifierInstitut de Neurosciences de la Timone [INT]
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorBELZEAUX, Raoul
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierHôpital Louis Mourier - AP-HP [Colombes]
hal.structure.identifierInstitut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
dc.contributor.authorDUBERTRET, Caroline
hal.structure.identifierLaboratoire de Neurosciences Intégratives et Cliniques - UFC (UR 481) [NEURO]
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierCentre d'Investigation Clinique de Besançon [Inserm CIC 1431]
dc.contributor.authorHAFFEN, Emmanuel
hal.structure.identifierEtablissement public de santé de Ville-Evrard [Neuilly-sur-Marne] [EPS]
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierUniversité Sorbonne Paris Nord
dc.contributor.authorJANUEL, Dominique
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierHôpital Henri Mondor
hal.structure.identifierInstitut Mondor de Recherche Biomédicale [IMRB]
dc.contributor.authorLEBOYER, Marion
hal.structure.identifierInstitut de Neurosciences de la Timone [INT]
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierDépartement Universitaire de Psychiatrie - [Hôpital Sainte Marguerite - APHM] [Hôpitaux Sud]
dc.contributor.authorLEFRERE, Antoine
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierInstitut Pascal [IP]
hal.structure.identifierCHU Clermont-Ferrand
dc.contributor.authorSAMALIN, Ludovic
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifier[GIN] Grenoble Institut des Neurosciences [GIN]
dc.contributor.authorPOLOSAN, Mircea
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierCentre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center [CRNL]
hal.structure.identifierCentre Hospitalier le Vinatier [Bron]
dc.contributor.authorREY, Romain
hal.structure.identifierCentre de recherche en épidémiologie et santé des populations [CESP]
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorROUX, Paul
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierCentre Psychothérapique de Nancy [Laxou] [CPN]
hal.structure.identifierImagerie Adaptative Diagnostique et Interventionnelle [IADI]
hal.structure.identifierHopital de Bohars - CHRU Brest [CHU - BREST ]
dc.contributor.authorSCHWAN, Raymund
hal.structure.identifierHopital de Bohars - CHRU Brest [CHU - BREST ]
dc.contributor.authorWALTER, Michel
hal.structure.identifierInstitut de Génomique Fonctionnelle [IGF]
hal.structure.identifierCentre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorCOURTET, Philippe
hal.structure.identifierCentre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierInstitut de Génomique Fonctionnelle [IGF]
dc.contributor.authorOLIE, Emilie
dc.date.accessioned2024-01-15T13:37:33Z
dc.date.available2024-01-15T13:37:33Z
dc.date.issued2023-12
dc.identifier.issn0924-9338en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/187171
dc.description.abstractEnIntroduction: Physical pain is a common issue in people with bipolar disorder (BD). It worsens mental health and quality of life, negatively impacts treatment response, and increases the risk of suicide. Lithium, which is prescribed in BD as mood stabilizer, has shown promising effects on pain.Methods: This naturalistic study included 760 subjects with BD (French FACE-BD cohort) divided in two groups: with and without self-reported pain (evaluated with the EQ-5D-5L questionnaire). In this sample, 176 subjects were treated with lithium salts. The objectives of the study were to determine whether patients receiving lithium reported less pain, and whether this effect was associated with the recommended mood stabilizing blood concentration of lithium.Results: Subjects with lithium intake were less likely to report pain (OR = 0.59, 95% CI [0.35-0.95]; p = 0.036) after controlling for sociodemographic variables, BD type, lifetime history of psychiatric disorders, suicide attempt, personality traits, current depression and anxiety levels, sleep quality, and psychomotor activity. Subjects taking lithium were even less likely to report pain when lithium concentration in blood was ≥0.5mmol/l (OR = 0.44, 95% CI [0.24-0.79]; p = 0.008).Discussion: This is the first naturalistic study to show lithium promising effect on pain in subjects suffering from BD after controlling for many confounding variables. This analgesic effect seems independent of BD severity and comorbid conditions. Randomized controlled trials are needed to confirm the analgesic effect of lithium salts and to determine whether lithium decreases pain in other vulnerable populations, such as people with chronic pain.
dc.description.sponsorshipSorbonne Universités à Paris pour l'Enseignement et la Recherche - ANR-11-IDEX-0004en_US
dc.description.sponsorshipFondaMental-Cohortes - ANR-10-COHO-0010en_US
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enBipolar disorder
dc.subject.enPain
dc.subject.enLithium
dc.title.enSubjects suffering from bipolar disorder taking lithium are less likely to report physical pain: a FACE-BD study
dc.typeArticle de revueen_US
dc.identifier.doi10.1192/j.eurpsy.2023.2476en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Psychiatrie et santé mentaleen_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologieen_US
bordeaux.journalEuropean Psychiatryen_US
bordeaux.page1-16en_US
bordeaux.hal.laboratoriesNutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFondation FondaMentalen_US
bordeaux.import.sourcehal
hal.identifierhal-04343891
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccCC BY-NC-NDen_US
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