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dc.rights.licenseopenen_US
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorBLONDOT, Marie-Lise
dc.contributor.authorBRUSS, Volker
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorKANN, Michael
dc.date.accessioned2023-11-20T15:35:28Z
dc.date.available2023-11-20T15:35:28Z
dc.date.issued2016-04-01
dc.identifier.issn1600-0641en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/184859
dc.description.abstractEnHepatitis B virus (HBV) replicates its genomic information in the nucleus via transcription and therefore has to deliver its partially double stranded DNA genome into the nucleus. Like other viruses with a nuclear replication phase, HBV genomes are transported inside the viral capsids first through the cytoplasm towards the nuclear envelope. Following the arrival at the nuclear pore, the capsids are transported through, using classical cellular nuclear import pathways. The arrest of nuclear import at the nucleoplasmic side of the nuclear pore is unique, however, and is where the capsids efficiently disassemble leading to genome release. In the latter phase of the infection, newly formed nucleocapsids in the cytosol have to move to budding sites at intracellular membranes carrying the three viral envelope proteins. Capsids containing single stranded nucleic acid are not enveloped, in contrast to empty and double stranded DNA containing capsids. A small linear domain in the large envelope protein and two areas on the capsid surface have been mapped, where point mutations strongly block nucleocapsid envelopment. It is possible that these domains are involved in the envelope--with capsid interactions driving the budding process. Like other enveloped viruses, HBV also uses the cellular endosomal sorting complexes required for transport (ESCRT) machinery for catalyzing budding through the membrane and away from the cytosol.
dc.language.isoENen_US
dc.subject.enActive Transport
dc.subject.enCell Nucleus
dc.subject.enEndosomal Sorting Complexes Required for Transport
dc.subject.enHepatitis B virus
dc.subject.enHumans
dc.subject.enViral Envelope Proteins
dc.subject.enVirion
dc.subject.enVirus Assembly
dc.subject.enVirus Replication
dc.title.enIntracellular transport and egress of hepatitis B virus.
dc.title.alternativeJ Hepatolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.jhep.2016.02.008en_US
dc.subject.halSciences du Vivant [q-bio]/Microbiologie et Parasitologieen_US
dc.identifier.pubmed27084037en_US
bordeaux.journalJournal of Hepatologyen_US
bordeaux.pageS49-S59en_US
bordeaux.volume64en_US
bordeaux.hal.laboratoriesMFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234en_US
bordeaux.issue1 Supplen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04296267
hal.version1
hal.date.transferred2023-11-20T15:35:29Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Hepatology&rft.date=2016-04-01&rft.volume=64&rft.issue=1%20Suppl&rft.spage=S49-S59&rft.epage=S49-S59&rft.eissn=1600-0641&rft.issn=1600-0641&rft.au=BLONDOT,%20Marie-Lise&BRUSS,%20Volker&KANN,%20Michael&rft.genre=article


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