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dc.rights.licenseopenen_US
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierInstitut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
dc.contributor.authorMALLET, Jasmina
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorGODIN, Ophelia
hal.structure.identifierFondation FondaMental [Créteil]
dc.contributor.authorDANSOU, Yecodji
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierInstitut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
dc.contributor.authorMAZER, Nicolas
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierInstitut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
dc.contributor.authorSCOGNAMIGLIO, Claire
hal.structure.identifierInstitut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
dc.contributor.authorBERNA, Fabrice
hal.structure.identifierCentre d'études et de recherche sur les services de santé et la qualité de vie [CEReSS]
dc.contributor.authorBOYER, Laurent
hal.structure.identifierInstitut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
dc.contributor.authorCAPDEVIELLE, Delphine
hal.structure.identifierInstitut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
dc.contributor.authorCHEREAU, Isabelle
hal.structure.identifierInstitut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
dc.contributor.authorD'AMATO, Thierry
hal.structure.identifierInstitut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
dc.contributor.authorDUBREUCQ, Julien
hal.structure.identifierInstitut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
dc.contributor.authorFOND, Guillaume
hal.structure.identifierInstitut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
dc.contributor.authorLEIGNER, Sylvain
hal.structure.identifierInstitut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
dc.contributor.authorLLORCA, Pierre-Michel
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
hal.structure.identifierInstitut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
dc.contributor.authorMISDRAHI, David
hal.structure.identifierInstitut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
dc.contributor.authorPASSERIEUX, Christine
hal.structure.identifierInstitut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
dc.contributor.authorREY, Romain
dc.contributor.authorPIGNON, Baptiste
hal.structure.identifierInstitut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
dc.contributor.authorURBACH, Mathieu
hal.structure.identifierInstitut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
dc.contributor.authorSCHORR, Benoit
dc.contributor.authorSCHURHOFF, Franck
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierInstitut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
dc.contributor.authorYANN, Le Strat
hal.structure.identifierFondation FondaMental [Créteil]
hal.structure.identifierInstitut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
dc.contributor.authorDUBERTRET, Caroline
dc.date.accessioned2023-11-09T10:20:12Z
dc.date.available2023-11-09T10:20:12Z
dc.date.issued2023-08-01
dc.identifier.issn1469-8978en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/184698
dc.description.abstractEnTobacco use is common in subjects with schizophrenia (SZ) and has sometimes been associated with better functioning in short-term studies. Only few studies embrace an extensive examination of tobacco influence on clinical, cognitive and therapeutic characteristics in stabilized SZ outpatients. The objective of the present study was to assess the association between cognitive performances and smoking status in SZ subjects. In total, 1233 SZ participants (73.9% men, mean age 31.5) were included and tested with a comprehensive battery. Tobacco status was self-declared (never-, ex-, or current smokers). Multivariable analyses including principal component analyses (PCA) were used. In total, 53.7% were smokers with 33.7% of them nicotine-dependent. Multiple factor analysis revealed that current tobacco smoking was associated with impaired general intellectual ability and abstract reasoning (aOR 0.60, 95% IC 0.41-0.88, = 0.01) and with a lifetime alcohol use disorder ( = 0.026) and a lifetime cannabis use disorder ( < 0.001). Ex- and never-smokers differed for age, mean outcome, cannabis history and medication [ex-smokers being older ( = 0.047), likely to have higher income ( = 0.026), a lifetime cannabis use disorder ( < 0.001) and higher CPZeq doses ( = 0.005)]. Premorbid IQ in the three groups significantly differed with, from higher to lower: ex-smokers, never-smoker, current smokers (all < 0.001). This study is the largest to date providing strong evidence that chronic smoking is associated with cognitive impairment in SZ, arguing against the self-medication hypothesis as a contributor to the high prevalence of smoking in SZ. Ex-smokers may also represent a specific subgroup. Longitudinal studies are warranted to determine the developmental impact of tobacco on neurocognition.
dc.language.isoENen_US
dc.subject.enMale
dc.subject.enHumans
dc.subject.enAdult
dc.subject.enFemale
dc.subject.enSchizophrenia
dc.subject.enCigarette Smoking
dc.subject.enTobacco
dc.subject.enMarijuana Abuse
dc.subject.enCognition
dc.title.enCurrent (but not ex) cigarette smoking is associated with worse cognitive performances in schizophrenia: results from the FACE-SZ cohort.
dc.title.alternativePsychol Meden_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1017/S0033291722002574en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed36073848en_US
bordeaux.journalPsychological Medicineen_US
bordeaux.page5279-5290en_US
bordeaux.volume53en_US
bordeaux.hal.laboratoriesNutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue11en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Psychological%20Medicine&amp;rft.date=2023-08-01&amp;rft.volume=53&amp;rft.issue=11&amp;rft.spage=5279-5290&amp;rft.epage=5279-5290&amp;rft.eissn=1469-8978&amp;rft.issn=1469-8978&amp;rft.au=MALLET,%20Jasmina&amp;GODIN,%20Ophelia&amp;DANSOU,%20Yecodji&amp;MAZER,%20Nicolas&amp;SCOGNAMIGLIO,%20Claire&amp;rft.genre=article


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