Night-to-night variability in sleep and amyloid beta burden in normal aging
dc.rights.license | open | en_US |
dc.contributor.author | JOUVENCEL, Aurore | |
dc.contributor.author | BAILLET, Marion | |
hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
dc.contributor.author | MEYER, Marie | |
dc.contributor.author | DILHARREGUY, Bixente | |
hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
dc.contributor.author | LAMARE, Frederic | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | PERES, Karine | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | HELMER, Catherine | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | DARTIGUES, Jean-Francois
ORCID: 0000-0001-9482-5529 IDREF: 058586105 | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | AMIEVA, Helene | |
hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
dc.contributor.author | MAYO, Willy | |
dc.contributor.author | CATHELINE, Gwenaëlle | |
dc.date.accessioned | 2023-11-07T14:07:45Z | |
dc.date.available | 2023-11-07T14:07:45Z | |
dc.date.issued | 2023-07-01 | |
dc.identifier.issn | 2352-8729 | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/184661 | |
dc.description.abstractEn | Alzheimer's disease is associated with sleep disturbances and accumulation of cerebral amyloid beta. The objective was to examine whether actigraphy-detected sleep parameters might be biomarkers for early amyloid burden. Participants underwent a week of actigraphy and an amyloid positron emission tomography (PET) scan. Sleep duration and continuity disruption (sleep fragmentation and nocturnal awakenings) were extracted and compared between amyloid-positive and amyloid-negative participants. Then multiple linear regressions were used between mean or night-to-night intra-individual variability (standard deviation) of sleep parameters and brain amyloid burden in a voxel-wise analysis. Eighty-six subjects were included (80.3 ± 5.4 years; 48.8% of women). Amyloid-positive participants had a higher variability of sleep fragmentation compared to amyloid-negative participants. This parameter was associated with a higher amyloid burden in the frontal and parietal regions, and in the precuneus, in the whole sample. This study highlights the relevance of using variability in sleep continuity as a potential biomarker of early amyloid pathogenesis. | |
dc.description.sponsorship | METAPROFILE : Recherche de marqueurs précoces des perturbations métaboliques associées à la prise de poids par une approche métabolimique | en_US |
dc.language.iso | EN | en_US |
dc.rights | Attribution-NonCommercial 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/us/ | * |
dc.subject.en | Actigraphy | |
dc.subject.en | Aging | |
dc.subject.en | Amyloid | |
dc.subject.en | Intra-individual variability of sleep | |
dc.subject.en | PET | |
dc.subject.en | Sleep | |
dc.title.en | Night-to-night variability in sleep and amyloid beta burden in normal aging | |
dc.title.alternative | Alzheimers Dement (Amst) | en_US |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1002/dad2.12460 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
dc.identifier.pubmed | 37745892 | en_US |
bordeaux.journal | Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring | en_US |
bordeaux.page | e12460 | en_US |
bordeaux.volume | 15 | en_US |
bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
bordeaux.issue | 3 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INSERM | en_US |
bordeaux.institution | CNRS | |
bordeaux.team | ACTIVE | en_US |
bordeaux.team | LEHA | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
bordeaux.identifier.funderID | Fondation Plan Alzheimer | en_US |
bordeaux.identifier.funderID | GE Healthcare | en_US |
bordeaux.identifier.funderID | Mutualité Sociale Agricole | en_US |
bordeaux.identifier.funderID | Caisse Centrale de la Mutualité Sociale Agricole | en_US |
bordeaux.identifier.funderID | Caisse nationale de solidarité pour l'autonomie | en_US |
bordeaux.identifier.funderID | Direction Générale de l’offre de Soins | en_US |
bordeaux.identifier.funderID | Fondation pour la Recherche Médicale | en_US |
bordeaux.identifier.funderID | Mutuelle Générale de l'Education Nationale | en_US |
bordeaux.identifier.funderID | Conseil régional de Bourgogne-Franche-Comté | en_US |
bordeaux.identifier.funderID | Conseil Régional Aquitaine | en_US |
bordeaux.import.source | pubmed | |
hal.identifier | hal-04273799 | |
hal.version | 1 | |
hal.date.transferred | 2023-11-07T14:07:48Z | |
hal.popular | non | en_US |
hal.audience | Internationale | en_US |
hal.export | true | |
workflow.import.source | pubmed | |
dc.rights.cc | Pas de Licence CC | en_US |
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