JOUVENCEL, Aurore; BAILLET, Marion; MEYER, Marie; DILHARREGUY, Bixente; LAMARE, Frederic; PERES, Karine; HELMER, Catherine; DARTIGUES, Jean-Francois; AMIEVA, Helene; MAYO, Willy; CATHELINE, Gwenaëlle

doi:10.1002/dad2.12460

Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]

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Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 2023-07-01, vol. 15, n° 3, p. e12460

Resumen en inglés

Alzheimer's disease is associated with sleep disturbances and accumulation of cerebral amyloid beta. The objective was to examine whether actigraphy-detected sleep parameters might be biomarkers for early amyloid burden. Participants underwent a week of actigraphy and an amyloid positron emission tomography (PET) scan. Sleep duration and continuity disruption (sleep fragmentation and nocturnal awakenings) were extracted and compared between amyloid-positive and amyloid-negative participants. Then multiple linear regressions were used between mean or night-to-night intra-individual variability (standard deviation) of sleep parameters and brain amyloid burden in a voxel-wise analysis. Eighty-six subjects were included (80.3 ± 5.4 years; 48.8% of women). Amyloid-positive participants had a higher variability of sleep fragmentation compared to amyloid-negative participants. This parameter was associated with a higher amyloid burden in the frontal and parietal regions, and in the precuneus, in the whole sample. This study highlights the relevance of using variability in sleep continuity as a potential biomarker of early amyloid pathogenesis.< Leer menos

Palabras clave en inglés

Actigraphy

Aging

Amyloid

Intra-individual variability of sleep

PET

Sleep

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https://oskar-bordeaux.fr/handle/20.500.12278/184661

DOI

http://dx.doi.org/10.1002/dad2.12460

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METAPROFILE : Recherche de marqueurs précoces des perturbations métaboliques associées à la prise de poids par une approche métabolimique

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Night-to-night variability in sleep and amyloid beta burden in normal aging

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Night-to-night variability in sleep and amyloid beta burden in normal aging

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Centros de investigación