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dc.rights.licenseopenen_US
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorMOREL, Jean-Luc
dc.contributor.authorMOKRZYCKI, Nathalie
dc.contributor.authorLIPPENS, Guy
dc.contributor.authorDROBECQ, Hervé
dc.contributor.authorSAUTIÈRE, Pierre
dc.contributor.authorHUGUES, Michel
dc.date.accessioned2023-10-17T10:46:20Z
dc.date.available2023-10-17T10:46:20Z
dc.date.issued2022-11-10
dc.identifier.issn2072-6651en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/184466
dc.description.abstractEnThe pharmacology of calcium-activated chloride current is not well developed. Peptides from scorpion venom present potent pharmacological actions on ionic conductance used to characterize the function of channels but can also be helpful to develop organic pharmacological tools. Using electrophysiological recording coupled with calcium measurement, we tested the potent effect of peptides extracted from venom on the calcium-activated chloride current expressed in smooth muscle cells freshly dissociated from rat portal veins. We identified one peptide which selectively inhibited the chloride conductance without effects on either calcium signaling or calcium and potassium currents expressed in this cell type. The synthetic peptide had the same affinity, but the chemical modification of the amino acid sequence altered the efficiency to inhibit the calcium-activated chloride conductance.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enRats
dc.subject.enAnimals
dc.subject.enScorpion Venoms
dc.subject.enChloride Channels
dc.subject.enCalcium
dc.subject.enChlorides
dc.subject.enMyocytes
dc.subject.enSmooth Muscle
dc.subject.enPeptides
dc.title.enCharacterization of a Family of Scorpion Toxins Modulating Ca2+-Activated Cl- Current in Vascular Myocytes
dc.title.alternativeToxins (Basel)en_US
dc.typeArticle de revueen_US
dc.identifier.pubmed36356031en_US
bordeaux.journalToxinsen_US
bordeaux.volume14en_US
bordeaux.hal.laboratoriesInstitut de neurosciences cognitives et intégratives d'Aquitaine (INCIA) - UMR 5287en_US
bordeaux.issue11en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDCentre National d’Etudes Spatialesen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
bordeaux.import.sourcepubmed
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcepubmed
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Toxins&rft.date=2022-11-10&rft.volume=14&rft.issue=11&rft.eissn=2072-6651&rft.issn=2072-6651&rft.au=MOREL,%20Jean-Luc&MOKRZYCKI,%20Nathalie&LIPPENS,%20Guy&DROBECQ,%20Herv%C3%A9&SAUTI%C3%88RE,%20Pierre&rft.genre=article


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