MOREL, Jean-Luc; MOKRZYCKI, Nathalie; LIPPENS, Guy; DROBECQ, Hervé; SAUTIÈRE, Pierre; HUGUES, Michel

MOREL, Jean-Luc
Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]

MOKRZYCKI, Nathalie

LIPPENS, Guy

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Toxins. 2022-11-10, vol. 14, n° 11

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The pharmacology of calcium-activated chloride current is not well developed. Peptides from scorpion venom present potent pharmacological actions on ionic conductance used to characterize the function of channels but can also be helpful to develop organic pharmacological tools. Using electrophysiological recording coupled with calcium measurement, we tested the potent effect of peptides extracted from venom on the calcium-activated chloride current expressed in smooth muscle cells freshly dissociated from rat portal veins. We identified one peptide which selectively inhibited the chloride conductance without effects on either calcium signaling or calcium and potassium currents expressed in this cell type. The synthetic peptide had the same affinity, but the chemical modification of the amino acid sequence altered the efficiency to inhibit the calcium-activated chloride conductance.< Leer menos

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Rats

Animals

Scorpion Venoms

Chloride Channels

Calcium

Chlorides

Myocytes

Smooth Muscle

Peptides

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https://oskar-bordeaux.fr/handle/20.500.12278/184466

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Institut de neurosciences cognitives et intégratives d'Aquitaine (INCIA) - UMR 5287

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Characterization of a Family of Scorpion Toxins Modulating Ca2+-Activated Cl- Current in Vascular Myocytes

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